非编码RNA分子标志物对脓毒症临床价值的研究进展

Clinical value of non-coding RNA molecular markers for sepsis

脓毒症和脓毒性休克是急危重症医学面临的重要临床问题,是重症加强治疗病房(ICU)患者的首位死亡原因,因此对其进行早期诊断和治疗显得特别重要。最近,对脓毒症患者非编码RNA全基因组表达分析显示,与健康者相比,超过80%有差异性表达。这些分子在生物过程中发挥重要作用,包括先天免疫、线粒体功能和细胞凋亡,微小RNA(miRNA)、长链非编码RNA(lncRNA)和环状非编码RNA(circRNA)等非编码RNA越来越多地被认为是各种信号转导途径的调节剂。通过对研究可能作为脓毒症分子标志物的非编码RNA的相关文献进行综述,讨论调节性非编码RNA靶向治疗脓毒症的潜力,并评估其临床价值。

Sepsis and septic shock are important clinical problems in critically ill patients,accounting for the first cause of death in intensive care unit(ICU).Therefore,early diagnosis and treatment are particularly important.Recently,genome-wide expression analysis of non-coding RNA in septic patients showed that more than 80%were differentially expressed compared with healthy individuals.These molecules play important roles in biological processes,including innate immunity,mitochondrial function and apoptosis.Therefore,a class of non-coding RNAs such as microRNA(miRNA),long-chain non-coding RNA(lncRNA)and circular non-coding RNA(circRNA)are increasingly recognized as a regulator of various signaling pathways.The potential of regulatory non-coding RNA target to treat sepsis was discussed by studying non-coding RNAs that might serve as molecular markers of sepsis,and its clinical value was evaluated.