脾脏介导的炎症反应在创伤性ARDS中作用的研究现状

Current status of spleen-mediated inflammatory response in traumatic acute respiratory distress syndrome

急性呼吸窘迫综合征(ARDS)被认为是全身炎症反应综合征(SIRS)的肺部表现,常作为疾病的并发症出现,使患者的预后恶化。近年来,创伤的发生率逐年升高,严重创伤可导致SIRS,是ARDS的常见危险因素之一。脾脏作为机体最大的外周免疫器官,所含有的大量免疫细胞及分泌的炎性因子在创伤性ARDS形成中起重要作用。近年来,通过抑制脾源性炎症反应来治疗ARDS的益处逐渐被发现,为ARDS的治疗提供了新思路。因此,探讨脾脏介导的炎症反应在创伤性ARDS中作用的研究现状对于创伤性ARDS的防治有重要意义。本文总结脾脏介导的炎症反应在创伤性ARDS发生过程中的作用及ARDS救治方法的研究现状,以探讨创伤性ARDS的防治新方法。

Acute respiratory distress syndrome(ARDS)is considered to be a pulmonary manifestation of systemic inflammatory response syndrome(SIRS),often occurring as a complication of disease,and worsening the prognosis of patients.In recent years,the incidence of trauma has increased year by year.Severe trauma can lead to SIRS,which is one of the common risk factors of ARDS.The spleen is the largest peripheral immune organ of the body,containing a large number of immune cells and secreting inflammatory factors.The inflammatory factors play an important role in the formation of traumatic ARDS.In recent years,the benefits of treating ARDS by inhibiting spleen-induced inflammatory response have gradually been discovered,providing new ideas for the treatment of ARDS.Therefore,the research status of spleen-mediated inflammatory response in traumatic ARDS is of great significance for the prevention and treatment of traumatic ARDS.This article reports the spleen-mediated systemic inflammatory response,the role of inflammatory mediators in the development of ARDS,and the current state of research on ARDS treatment to explore new approaches to the prevention and treatment of traumatic ARDS.