β-硅酸二钙骨水泥的水化改性及其生物活性的研究

The Hydration Modification and Bioactivity of Beta-dicalcium Silicate Bone Cements

成功地合成了含球霰石β-硅酸二钙生物骨水泥,目的是为了降低β-硅酸二钙骨水泥水化产物Ca(OH)2的碱性对生物材料的不利影响,并提高β-硅酸二钙骨水泥的生物活性。将含球霰石与不含球霰石的β-硅酸二钙骨水泥浸泡到人体模拟液(SBF)中3天,使用XRD、SEM、EDS和FT-IR对其表面形成的羟基磷灰石进行分析与研究,发现含球霰石的β-硅酸二钙骨水泥的体外生物活性明显提高了;对水化改性后的β-硅酸二钙的凝结时间也进行了评价。结果表明,含球霰石的β-硅酸二钙骨水泥的羟基磷灰石形成能力更好,凝结时间(12±2min)适合于临床操作的使用,是极具应用前景的骨修复替代材料。

β-Ca2SiO4 bone cement has been successfully synthesized. The purpose is to reduce the adverse effect caused by the hydration product Ca(OH)2 in the β-Ca2SiO4 bone cement, and improve the bioactivity of the β-Ca2SiO4 bone cement. The in vitro bioactivity of β-Ca2SiO4bone cements was evaluated compared with β-Ca2SiO4 bone cement without vaterite by soaking in simulated body fluid (SBF) for the same time (3 days). The formation abilities of hydroxyapatite (HAp) on their surfaces were analyzed by XRD, SEM, EDS and FTIR. In addition, the setting time of vaterite-containing cement was measured. Experimental results demonstrated that vaterite containing β-Ca2SiO4bone cements could easily induce the formation of HAp on their surfaces after immersion in SBF. And vaterite-containing β-Ca2SiO4 bone cement has much better HAp forming ability and more appropriate setting time (12±2min) than the without, which can be a satisfactory substrate for the bone repairing.