小檗碱治疗阿尔茨海默病作用机制的研究进展

Research progress of role of berberine in Alzheimer’s disease

小檗碱是从黄连中提取的一种异喹啉类生物碱,具有多种药理作用。研究表明,小檗碱可通过影响神经递质、抗氧化应激、调节代谢及其他多靶点途径治疗AD,但作用机制尚不明确。本文对小檗碱治疗AD作用机制的相关文献进行综述。

Berberine (BBR) is a natural isoquinoline alkaloid extracted from coptis chinensis. Berberine has several pharmacological activities, including disease-resistant microorganisms, anti-inflammatory, anti-tumor, heart protection, hypoglycemia, regulation of lipid metabolism and immunomodulatory properties. However, BBR's effects on neurodegenerative diseases remained relatively unexplored until its ability to stunt AD progression was characterized. Substantial studies suggest that berberine may be beneficial to AD by limiting the pathogenesis of extracellular amyloid plaques and intracellular neurofibrillary tangles. The studies in recent years have also found that berberine can additionally treat AD by affecting neurotransmitter, anti-oxidative stress, metabolism and other multi-target pathways. This article discusses the treatment pathway of berberine on AD, and summarizes the inhibition mechanism of berberine on AD.