长脉冲1064nm激光联合酮康唑软膏封包病甲治疗甲真菌病的临床疗效观察

Clinical observation of long-pulsed 1064nm laser combined with ketoconazole ointment in the treatment of onychomycosis

目的观察长脉冲1064 nm激光联合酮康唑软膏封包病甲治疗甲真菌病的临床疗效。方法 将73例甲真菌病门诊患者随机分为两组:联合组(37例,病甲75个)采用长脉冲1064 nm激光联合酮康唑软膏封包病甲治疗;对照组(36例,病甲87个)单纯使用激光治疗。每周1次,连续治疗8周,治疗6个月后随访评估。比较两种方法治疗甲真菌病的临床有效率,观察1064 nm激光联合酮康唑软膏封包病甲治疗甲真菌病患者的临床疗效。结果 联合组治疗甲真菌病的总的临床有效率(74.67%)高于对照组(63.22%),3种临床类型在联合组的临床有效率均高于对照组,尤其近端甲下型(PSO)的临床有效率明显提高,但差异无统计学意义;当9≤SCIO≤15时,联合组治疗甲真菌病的临床有效率高于对照组,差异有统计学意义。结论 对于9≤SCIO≤15的甲真菌病患者,长脉冲1064 nm激光联合酮康唑软膏封包病甲治疗甲真菌病的临床疗效显著高于单纯激光治疗。

Objective To observe the clinical efficacy of long-pulsed 1064nm laser combined with ketoconazole ointment in the treatment of onychomycosis. Methods Seventy-three outpatients with onychomycosis were randomly divided into two groups: the combined group (37 cases, 75 affected nails) was treated with 1064nm long-pulsed laser combined with ketoconazole ointment encapsulation of affected nails;the control group (36 cases, 87 affected nails) was treated with laser only. The patients were treated once a week for 8 weeks and followed up after 6 months. Results The total clinical effective rate (74.67%) of the combined group was higher than that of the control group (63.22%).The clinical effective rate of the three clinical types in the combined group was also higher than that of the control group, especially the proximal subungual type (PSO), but there was no significant difference in statistics. The clinical effective rate of onychomycosis with a score of 9 ≤ SCIO≤15 in the combined group was higher than that of the control group. Conclusion The clinical efficacy of long-pulsed 1064nm laser combined with ketoconazole ointment in the treatment of onychomycosis patients with SCIO value of 9 ≤ SCIO ≤ 15 was significantly higher than that of laser only.