美托洛尔联合丙种球蛋白对儿童扩张型心肌病心力衰竭的疗效观察

Observation on curative effects of metoprolol combined with gamma globulin in treatment of Children with dilated cardiomyopathy and heart failure

目的分析对儿童扩张型心肌病心力衰竭患者实行美托洛尔与丙种球蛋白联合治疗的临床效果。方法选取70例在我院接受治疗的儿童扩张型心肌病心力衰竭患者作为临床研究对象,入院时间为2012年10月~2018年7月,以治疗方式的不同分两组,实行美托洛尔治疗的患者设为对照组,实行美托洛尔与丙种球蛋白联合治疗的患者设为观察组,比较患者的临床疗效情况。结果经治疗后,观察组患者的LVIDd(41.25±3.09)mm、LVIDs(40.21±3.21)mm以及心率(84.74±8.32)次/min的值均显著低于对照组患者的LVIDd(48.65±3.56)mm、LVIDs(45.62±3.76)mm以及心率(99.88±9.65)次/min;观察组患者的LVEF值(47.01±4.23)%显著高于对照组患者的LVEF值(40.22±3.98)%;观察组患者治疗效果为97.14%显著高于对照组的治疗效果74.29%,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。比较两组的治疗满意度,观察组显著高于对照组,差异有统计学意义(P<0.05)。结论给予儿童扩张型心肌病(DCM)心力衰竭患者行美托洛尔与丙种球蛋白联合治疗可有效提高临床治疗效果,有较高的临床应用价值。

Objective To analyze the clinical curative effects of metoprolol combined with gamma globulin in treatment of children with dilated cardiomyopathy and heart failure. Methods 70 children with dilated cardiomyopathy (DCM) and heart failure who were treated in our hospital from October 2012 to July 2018 were selected as the clinical research objects. According to different treatment methods,they were divided into two groups.Patients treated with metoprolol were selected as the control group while patients treated with metoprolol combined with gamma globulin were selected as the observation group.Clinical curative effects of patients were compared. Results After treatment,values of LVIDd,LVIDs and heart rate in the observation group were respectively (41.25±3.09)mm,(40.21±3.21)mm and(84.74±8.32)times/min,significantly lower than (48.65±3.56)mm,(45.62±3.76)mm and (99.88±9.65)times/min in the control group.The value of LVEF of patients in the observation group was (47.01±4.23)mm,significantly higher than (40.22±3.98)mm of the control group.The effective rate of treatment of the observation group was 97.14%,significantly higher than 74.29% of the control group.The differences were statistically significant (P < 0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups (P > 0.05).The satisfaction with treatment of the observation group was higher than that of the control group and the difference was statistically significant (P < 0.05). Conclusion Metoprolol combined with gamma globulin in treatment of children with dilated cardiomyopathy (DCM) and heart failure can effectively improve the clinical curative effects,which has relatively high clinical values.