孟鲁司特纳治疗小儿轻、中度持续性哮喘分析

Analysis on montelukast in treatment of mild to moderate persistent asthma in Children

目的研究孟鲁司特纳治疗小儿轻、中度持续性哮喘的效果。方法根据“双盲随机分组原则”将2016年8月~2017年7月本院接收的轻、中度持续性哮喘患儿104例分为对照组(常规对症治疗)和观察组(加用孟鲁司特纳治疗),每组52例。将两组的临床效果、实验室指标、肺功能指标、不良反应发生情况、复发情况进行比对。结果观察组轻、中度持续性哮喘患儿的临床总有效率、治疗后的IL-12、FEV1高于对照组(P<0.05),治疗后的IL-4、IgE水平以及复发率低于对照组(P<0.05);治疗后的肺功能指标明显优于治疗前(P<0.05),两组均无明显不良反应发生。结论孟鲁司特纳应用于小儿轻、中度持续性哮喘治疗中安全有效。

Objective To study the curative effects of montelukast in treatment of mild to moderate persistent asthma in children. Methods According to the principle of double blind randomized grouping, 104 children with mild to moderate persistent asthma who were admitted to our hospital from August 2016 to July 2017 were divided into the control group (routine symptomatic treatment) the and observation group (combined with montelukast for treatment),with 52 cases in each group.The clinical curative effects,laboratory indexes,lung function indexes,adverse reactions and recurrence were compared between the two groups. Results The total effective rate,IL-12 and FEV1 after treatment of children with mild and moderate persistent asthma in the observation group were higher than those in the control group (P < 0.05).Levels of IL-4,IgE and recurrence rate were lower than those in the control group (P < 0.05),and the lung function indexes after treatment were significantly better than those before treatment (P < 0.05). No significant adverse reactions occurred in either group. Conclusion Montelukast is safe and effective in the treatment of mild and moderate persistent asthma in children.