PI3K/AKT通路介导口腔鳞状细胞癌发生发展相关因素的研究进展

Research progress of factors related to the occurrence and development of oral squamous cell carcinoma mediated by PI3K/AKT pathway

口腔癌(oral cancer)是唇或口腔的恶性肿瘤,它是世界上10种最常见的恶性肿瘤之一,90%的口腔癌病例是口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)。PI3K/AKT信号转导通路作为细胞内重要的信号转导通路之一,与多种恶性肿瘤(包括OSCC)的发生、发展关系密切。该文主要对PI3K/AKT通路介导OSCC发生、发展、转移等相关因素做一综述。

Oral cancer is a malignant tumor of the lips or mouth, which is one of the 10 most common cancers in the world. 90% of oral cancer cases are oral squamous cell carcinoma(OSCC). PI3 K/AKT signal transduction pathway is one of the important signal transduction pathways in cells, and has close relationship with the occurrence and development of many malignant tumors(including OSCC). This article mainly reviews the PI3 K/AKT pathway mediating the occurrence, development and metastasis of oral squamous cell carcinoma.