Vimentin、CA125的表达及其变化与上皮性卵巢癌预后分析

Expression of vimentin and CA125 and prognosis analysis of epithelial ovarian cancer

①目的探讨Vimentin、CA125的表达及其变化与上皮性卵巢癌预后分析。②方法收集91例上皮性卵巢癌患者作为研究对象,采用免疫组化的方法测定卵巢组织中Vimentin的表达,CA125变化与临床病理特征及无进展均生存时间(PFS)、总生存时间(OS)之间的关系。采用Kaplan-Meier法对PFS及OS进行单因素分析。③结果Vimentin表达与组织分化、临床分期相关(χ^2=36.708、36.900,P均<0.05),与病理类型及术后化疗无关(P>0.05)。Kaplan-Meier单因素分析,结果显示:PFS、OS与组织分化、临床分期、术后化疗及术后3程化疗后CA125转归倍数、Vimentin表达有关,与病理类型无关。④结论Vimentin表达及术前CA125与临床病理特征密切相关,Vimentin表达及术前CA125及3程化疗后CA125转归倍数与上皮性卵巢癌的PFS、OS密切相关,可做为上皮性卵巢癌预后的预测因子。

Objective To investigate the expression of vimentin and CA125 and epithelial ovarian cancer prognosis analysis.Methods 91 cases of epithelial ovarian cancer patients were selected as the research object,the expression of vimentin were analyzed by immunohistochemical menthods,the relationship among vimentin,CA125 change and the clinical pathological features in ovarian tissue and progression-free survival(PFS),the overall survival(OS) time.Kaplan-Meier menthod was used to analyze PFS and OS for single factor.Results The expression of vimentin associated with tissue differentiation,clinical stage(χ^2=36.708,36.900, P <0.05).Kaplan and Meier single factor analysis,the result shows that PFS,OS and tissue differentiation,clinical stage,chemotherapy after surgery and postoperative multiple CA125 after routine chemotherapy outcome 3,vimentin expression was correlation,has nothing to do with the pathological types.Conclusion The expression of vimentin and preoperative CA125 is closely related to the clinical pathological features,vimentin expression and preoperative CA125 and multiple CA125 after routine chemotherapy outcome 3 are closely associated with epithelial ovarian cancer of PFS,OS,but as a predictor of epithelial ovarian cancer cases.