期刊文献+

丝裂原活化蛋白激酶参与调控克罗恩病肠纤维化的研究进展 被引量:1

下载PDF
导出
摘要 肠壁纤维化是克罗恩病(CD)的常见并发症,其持续发展会导致肠梗阻等严重并发症。目前CD肠壁纤维化的研究是相关领域的研究热点。丝裂原活化蛋白激酶(MAPK)参与器官纤维化的发生发展已被很多实验证实。作者对MAPK通过介导肿瘤坏死因子、Rho激酶、胰岛素样生长因子-Ⅰ等信号通路参与CD肠纤维化的研究进展进行综述。
出处 《东南大学学报(医学版)》 CAS 2019年第3期554-558,共5页 Journal of Southeast University(Medical Science Edition)
  • 相关文献

参考文献4

二级参考文献35

  • 1Maria Gazouli,Ioanna Pachoula,Ioanna Panayotou,Gerassimos Mantzaris,George Chrousos,Nicholas P Anagnou,Eleftheria Roma-Giannikou.NOD2/CARD15 , ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn’s disease[J].World Journal of Gastroenterology,2010,16(14):1753-1758. 被引量:7
  • 2李元新.克罗恩病肠梗阻的外科治疗[J].实用临床医药杂志,2005,9(9):36-37. 被引量:12
  • 3汪建平.克罗恩病的流行病学及外科治疗[J].中华胃肠外科杂志,2007,10(3):199-201. 被引量:8
  • 4Martin JW Meijer,Marij AC Mieremet-Ooms,Ruud A van Hogezand,Cornelis BHW Lamers,Daniel W Hommes,Hein W Verspaget.Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease[J].World Journal of Gastroenterology,2007,13(21):2960-2966. 被引量:15
  • 5Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor [ J]. Physiol Rev, 1999, 79 (4) : 1283- 1316.
  • 6Tsutsumi N, Yonemitsu Y, Shikada Y, et al. Essential role of PDGFR alpha-p70S6K signaling in mesenchymal cells during therapeutic and tumor angiogenesis in vivo : role of PDGFR alpha during angiogenesis [J]. Circ Res, 2004, 94(9): 1186-1194.
  • 7Borkham-Kamphorst E, lerrmann J, Stoll D, et al. Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis [ J ]. Lab Invest, 2004, 84 ( 6 ) : 766-777.
  • 8Zhong W, Shen WF, Ning BF, et al. Inhibition of extracellular signal-regulated kinase lby adenovirus mediated small interfering RNA attenuates hepatic fibrosis in Rats [ J ]. Hepatology, 2009, 50 (5) : 1524-1536.
  • 9Si HF, Lv X, Guo A, et al.Suppressive effect of lefiunomide on rat hepatic stellate cell proliferation involves on PDGF-BB-elicited activation of three mitogen-activated protein kinases [J]. Cytokine, 2008, 42(1): 24-31.
  • 10Jeong WI, Park O, Radaeva S, et al. Liver STATI inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity [ J ]. Hepatology, 2006, 44 (6) : 1441-1451.

共引文献68

同被引文献13

引证文献1

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部