加味补脑熄风止痉汤联合醒脑开窍针法对老年帕金森病患者血清MDA、SOD水平的影响

Effect of Jiawei Bunaoxifeng Zhizjing Decoction Combined with Xingnao Kaiqiao Acupuncture on Serum MDA and SOD Levels in Elderly Patients with Parkinson’s Disease

目的分析老年帕金森病(PD)采用加味补脑熄风止痉汤与醒脑开窍针法联合治疗对患者血清MDA(丙二醛)、SOD(超氧化物歧化酶)水平的影响。方法选取本院2014年9月~2017年10月收治的74例PD患者,以随机数字表法分组,观察组37例和对照组37例,对照组均服用左旋多巴药物,观察组加以醒脑开窍针法与加味补脑熄风止痉汤联合治疗,比较两组临床疗效(优良率)、治疗前后血清MDA、SOD水平及简易精神状况检查量表(MMSE)评分。结果观察组优良率较对照组高(P <0.05);治疗后观察组血清MDA较对照组低,血清SOD较对照组高(P <0.05);治疗后观察组MMSE评分较对照组高(P <0.05)。结论老年PD采用加味补脑熄风止痉汤与醒脑开窍针法联合治疗疗效显著,可降低血清MDA水平,提高SOD水平,改善患者精神状态。

Objective To analyze the effect of Jiawei Bunaoxifeng Zhizjing Decoction combined with Xingnao Kaiqiao Acupuncture on serum MDA (malondialdehyde) and SOD (superoxide dismutase) levels in elderly patients with Parkinson's disease (PD). Methods Seventy-four patients with PD who were admitted to our hospital from September 2014 to October 2017 were randomLy divided into three groups: 37 patients in the observation group and 37 patients in the control group. The control group was treated with levodopa and the observation group was treated with Jiawei Bunaoxifeng Zhizjing Decoction combined with Xingnao Kaiqiao Acupuncture. The clinical efficacy (excellent and good rate), serum MDA, SOD level and simple mental condition examination scale (MMSE) score before and after treatment were compared. Results The excellent and good rate of the observation group was higher than that of the control group (P < 0.05). The serum MDA of the observation group was lower than that of the control group, and the serum SOD was higher than that of the control group (P < 0.05). The MMSE score of the observation group was higher than that of the control group after treatment (P < 0.05). Conclusion The treatment of senile PD with Jiawei Bunaoxifeng Zhizjing Decoction and Xingnao Kaiqiao Acupuncture is effective, which can reduce serum MDA level, increase SOD level and improve mental state of patients.