生物钟Bmal1基因与肿瘤治疗的研究进展及未来新思路

Research progress and new ideas in circadian gene Bmal1 and oncotherapy

昼夜节律参与调节生物体的生命活动,使生物的生理活动呈周期性、有序性和协同性。Bmall1基因为昼夜节律体系的核心元件之一,在肿瘤组织和正常组织中存在不同程度的表达。Bmal1基因在不同的肿瘤中作用各异。因此,分析Bmal1在不同肿瘤发生过程中的作用能为临床早期发现和有效治疗肿瘤提供新的理论依据。近年来,随着时间医学的深入研究,依照人体生物节律与药代动力学相结合的时辰化疗已成为治疗肿瘤的重要方法。不同时间放疗会导致不同的放射敏感性,使得时辰放疗在肿瘤治疗中的地位日益突出。深入研究生物的昼夜节律性,能为肿瘤的治疗开启全新的视角。

Circadian rhythm plays a role in regulating life activities and contributes to periodicity, orderliness, and synergy in organisms. The Bmal1 gene is one of the core components of the circadian rhythm system;the level of Bmal1 expression differs between tumor and normal tissues. Studies have shown that Bmal1 plays different roles in different tumors. Therefore, understanding the role of Bmal1 in different tumorigenesis could provide a new theoretical basis for early detection or effective treatment of tumors. In recent years, with the in-depth studies on time-based approaches, chrono-chemotherapy, which combines pharmacokinetics and biotic rhythm, has become one of the important methods of tumor treatment. Radiotherapy at different times can lead to differences in radiosensitivity, which makes chrono-radiotherapy increasingly prominent in tumor treatment. In-depth studies on circadian rhythm in cancer biology could provide new perspectives for tumor treatment.