B超、超敏C反应蛋白及血脂水平联合检查在高龄H型高血压患者颈动脉血管斑块稳定性诊断的应用价值

Application value analysis of B-mode ultrasound,hypersensitive c-reactive protein and blood lipid levels in the diagnosis of carotid artery plaque stability in elderly patients with H-type hypertension

目的:研究B型超声、超敏C反应蛋白(hs-CRP)及血脂水平在高龄H型高血压患者颈动脉血管斑块稳定性诊断的应用价值。方法:选择150例老年高血压患者作为观察对象,将其按照年龄以及同型半胱氨酸水平的不同分成高龄H型高血压组、低龄H型高血压组,低龄非H型高血压组,另取同期接受体检的健康人员100例为对照组。分别采用彩色多普勒超声诊断仪检测各组人员的颈动脉斑块信息,采用酶联免疫吸附法检测hs-CRP水平,采用日立7600型全自动生化分析仪检测血脂指标水平。并分析H型高血压患者颈动脉斑块结构与年龄、血清H型高血压以及血脂水平的相关性。结果:高龄H型高血压组、低龄H型高血压组、低龄非H型高血压组、对照组颈动脉血管不稳定性斑块发生率呈逐渐降低趋势,且经单因素方差分析可得:各组间对比差异有统计学意义(均P<0.05)。高龄H型高血压组、低龄H型高血压组、低龄非H型高血压组、对照组血清hs-CRP、低密度脂蛋胆固醇(LDL-C)水平呈逐渐降低趋势,且经单因素方差分析可得:各组间对比差异均有统计学意义(均P<0.05)。经Pearson相关性分析可得:高龄H型高血压患者颈动脉血管不稳定斑块与年龄、hs-CRP、LDL-C水平呈正相关关系(均P<0.05)。结论:B型超声、hs-CRP及血脂水平联合检测可用于诊断高龄H型高血压患者颈动脉血管斑块稳定性情况。

Objective:To investigate the value of B-mode ultrasound,hypersensitive c-reactive protein(hs-CRP)and blood lipid levels in the diagnosis of carotid artery plaque stability in elderly patients with h-type hypertension.Methods:150 cases of senile hypertension patients as research object,its according to age and homocysteine levels were divided into the elderly H hypertension group,the young H hypertension group,the young non H hypertension group,another the same period in the health checkup in our personnel 100 cases were seletctd as the control group.Carotid artery plaque information of each group was detected by color doppler ultrasound diagnostic instrument,hs-CRP level was detected by enzyme linked immunosorbent assay,and serum lipid level was detected by Hitachi 7600 automatic biochemical analyzer.The relationship between carotid artery plaque structure and age,serum h-type hypertension and blood lipid level in patients with h-type hypertension was analyzed.Results:The incidence of carotid artery instability plaque in the elderly H hypertension group,the young H hypertension group,the young non H hypertension group,and the control group showed a gradually decreasing trend,and one-way anova showed that there were statistically significant differences between the groups(all P<0.05).The serum hs-CRPand LDL-C levels of the elderly H hypertension group,the young H hypertension group,the young non H hypertension group and the control group showed a gradually decreasing trend,and one-way anova showed that there were statistically significant differences between the groups(all P<0.05).Pearson correlation analysis showed that carotid artery plaque instability was positively correlated with age,hs-CRP and LDL-C levels in elderly patients with type H hypertension(all P<0.05).Conclusion:Combined B-mode ultrasound,hs-CRP and lipid level detection can be used to diagnose the stability of carotid artery plaque in elderly patients with h-type hypertension.