针灸背俞穴结合局部围刺、放血治疗黄褐斑伴月经不调的效果及对血清SOD和MDA水平影响

Effects of Plum Blossom Needle Kowtowing on Bichu Point Combined with Local Circumference Prick,Bloodletting Treatment of Chloasma with Menstrual Disorder and its Effect on Serum SOD and MDA Levels

目的分析梅花针叩刺背俞穴结合局部围刺、放血治疗黄褐斑伴月经不调的效果及对血清超氧化物歧化酶(SOD)和丙二醛(MDA)水平影响。方法选取我院2016年1月—2018年1月收治的黄褐斑伴月经不调患者86例,根据治疗方法不同分为对照组和观察组。对照组患者采用局部围刺、放血治疗,观察组患者采用梅花针叩刺背俞穴结合局部围刺、放血治疗,分析2组患者治疗2个疗程后的临床效果。结果观察组患者总有效率为88.37%,对照组为69.77%,观察组患者总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者月经不调症候评分、黄褐斑面积、黑素指数(MCI)比较,差异无统计学意义(P>0.05)。治疗后,观察组患者月经不调症候评分、黄褐斑面积、黑素指数MCI低于对照组,差异有统计学意义(P<0.05)。治疗前,2组患者VEGF、COX-2、SP、SOD、MDA水平比较,差异无统计学意义(P>0.05)。治疗后,观察组患者VEGF、SOD水平高于对照组,COX-2、SP、MDA水平低于对照组,差异有统计学意义(P<0.05)。结论梅花针叩刺背俞穴结合局部围刺、放血治疗黄褐斑伴月经不调疗效显著,可减少黄褐斑面积,改善月经不调症状,其机制可能与对VEGF、COX-2、SP、SOD、MDA水平的调节有关。

Objective In order to analyze the effects of pricking plum blossom needle on Bushu point combined with local circumference and bleeding treatment of chloasma with menstrual disorder and its effects on serum superoxide dismutase(SOD)and malondialdehyde(MDA)levels.Methods Eighty-six chloasma patients with irregular menstruation in our hospital from January 2016 to January 2018 were selected and divided into control group and observation group according to different treatment methods.The patients in the control group were treated with local circumference and bloodletting,while the patients in the observation group were treated with plum blossom acupuncture and local circumference.The clinical effects of the two groups were analyzed after two courses of treatment.Results The total effective rate was 88.37%in the observation group and 69.77%in the control group.The total effective rate in the observation group was higher than that in the control group(P<0.05).Before treatment,there were no significant differences in menstrual score,chloasma area and melanin index between the two groups(P>0.05).After treatment,the score of irregular menstruation,the area of chloasma and the MCI of melanin index in the observation group were significantly lower than those in the control group(P<0.05).Before treatment,there was no significant difference in COX-2,SP,SOD,MDA and vascular endothelial growth factor(VEGF),between the two groups(P>0.05).After treatment,the levels of VEGF,SOD in the observation group were higher than those in the control group,and the levels of COX-2,SP,MDA in the observation group were lower than those in the control group(P<0.05).Conclusion In combination with local circumference,hemostasis therapy of yellow brown spot with menorrhea is significant,which can reduce the area of yellow brown spot and improve the symptoms of menses,and its mechanism may be related to the regulation of VEGF,COX2,SP,SOD and MDA level.