CUGBP1、VEGF在膀胱癌中的表达及临床意义

Expression of CUGBP1 and VEGF in bladder cancer and their clinical significance

目的探讨膀胱癌组织中CUG连接蛋白1(CUGBP1)、血管内皮细胞生长因子(VEGF)的表达及其临床意义。方法选取山西省肿瘤医院2016年1月至2017年8月收集的80例手术后膀胱癌组织(膀胱癌组)和80例膀胱癌癌旁组织(癌旁组),采用免疫组织化学(SP)法检测两组标本中的CUGBP1、VEGF表达、分析二者的相互关系,并分析其在不同肿瘤直径、肿瘤分化程度、病理学分期、淋巴结转移、浸润深度的肿瘤组织中的表达差异。结果膀胱癌组织中的CUGBP1、VEGF表达阳性表达率分别为61.25%、66.25%,癌旁组织中分别为10.00%、13.75%,两组比较差异有统计学意义(P<0.05);膀胱癌组织中的CUGBP1、VEGF阳性表达呈显著的正相关关系(Spearman秩相关系数=0.527,P<0.05);中低分化膀胱癌、T3分期、发生淋巴结转移的膀胱癌组标本中CUGBP1阳性表达率高于高分化、T2分期、未发生淋巴结转移的膀胱癌组标本,差异有统计学意义(P<0.05);中低分化膀胱癌、T3分期、发生淋巴结转移、浸润达到肌层的膀胱癌组标本中VEGF阳性表达率高于高分化、T2分期、未发生淋巴结转移、浸润未达到肌层的膀胱癌组标本,差异有统计学意义(P<0.05)。结论CUGBP1、VEGF在膀胱癌组织中高表达,且与膀胱癌病理学特征有一定的相关性。

Objective To investigate the expression of CUG-linked protein 1(CUGBP1)and vascular endothelial growth factor(VEGF)in bladder cancer and its clinical significance.Methods Eighty cases of postoperative bladder cancer tissues(bladder cancer group)and 80 cases of para-carcinoma tissues of bladder cancer(paracance group)in Shanxi Cancer Hospital from January 2016 to August 2017 were collected.Immunohistochemistry(SP)method was used to detect the expressions of CUGBP1 and VEGF in the two groups.The differences of expression in tumors with different diameter,differentiation degree,pathological stage,lymph node metastasis and depth of invasion were analyzed.Results The positive expression rates of CUGBP1 and VEGF in bladder cancer tissues were 61.25%and 66.25%,respectively,and 10.00%and 13.75%in para-carcinoma tissues,respectively,and the difference between the two groups was statistically significant(P<0.05).There was a significant positive correlation between the expression of CUGBP1 and VEGF in the bladder cancer tissues(Spearman rank correlation coefficient=0.527,P<0.05).The positive expression rate of CUGBP1 in moderately and poorly differentiated bladder cancer,T3 stage and lymph node metastasis group was higher than that in highly differentiated,T2 stage and non-lymph node metastasis group(P<0.05).The positive expression rate of vascular endothelial growth factor was higher in moderately and poorly differentiated bladder cancer,T3 stage,lymph node metastasis and myometrial invasion than in highly differentiated,T2 stage,non-lymph node metastasis and myometrial invasion of bladder cancer(P<0.05).Conclusions The expression of CUGBP1 and vascular endothelial growth factor in bladder cancer tissues is high,which is correlated with the pathological characteristics of bladder cancer.