阿托伐他汀对冠心病心力衰竭患者心脏结构功能及炎症反应的影响

Effect of atorvastatin on heart structure function and inflammatory response in patients with coronary heart disease and heart failure

目的探讨阿托伐他汀治疗对冠心病心力衰竭患者心脏结构功能的调节效果。方法回顾性分析2016年1月至2018年1月在濮阳市安阳地区医院治疗的108例冠心病心力衰竭患者的临床资料,根据治疗方案不同将患者分为观察组(常规药物治疗+40mg/d阿托伐他汀治疗)与对照组(常规药物治疗+20mg/d阿托伐他汀治疗),每组54例。比较两组心脏结构功能[左室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、心搏出量(SV)、心脏指数(CI)]、炎症反应[超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]。结果观察组治疗6周后LVEF、CI与SV值均高于对照组,LVEDD、hs-CRP、IL-6与TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。结论冠心病心力衰竭患者在常规药物治疗基础上,采用40mg/d阿托伐他汀治疗,可进一步改善心脏结构功能,减轻炎症反应。

Objective To investigate the effect of atorvastatin on cardiac structure and function in patients with coronary heart disease and heart failure.Method Clinical data of 108 patients with coronary heart disease and heart failure treated in Anyang Regional Hospital of Puyang from January 2016 to January 2018 were retrospectively analyzed.According to treatment methods,the 108 patients were divided into observation group(routine drug treatment+atorvastatin 40 mg/d)and control group(routine drug treatment+20 mg/d atorvastatin),with 54 cases in each group.The cardiac structure function,such as left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),heart beat out the quantity(SV),cardiac index(CI),inflammation response,including hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor(TNF-α),were compared between the two groups.Results After 6 weeks of treatment,LVEF,CI and SV levels in the observation group were higher than those in the control group,LVEDD,hs-CRP,IL-6 and TNF-αlevels were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusions In patients with coronary heart disease and heart failure,40 mg/d atorvastatin can effectively improve cardiac structure function and reduce inflammation reactions.