摘要
目的探讨老年2型糖尿病(T2DM)合并非酒精性脂肪肝(NAFLD)与血尿酸水平的关系。方法回顾性分析2017年12月至2018年8月郑州大学第一附属医院收治的60岁以上的T2DM患者共225例,其中合并NAFLD 122例(DN组),不伴NAFLD者103例(DM组)。检测所有研究对象的年龄、体质指数(BMI)、血尿酸、总胆红素(TBIL)、直接胆红素(BILD)、间接胆红素(IBLD)、总胆汁酸(TBA)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)、三酰甘油(TG)、总胆固醇(TCHO)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(HbA1C),并进行统计学分析。结果DN组血尿酸、ALT、AST、GGT、BMI、TG水平高于DM组,年龄、病程低于DM组,差异有统计学意义(P<0.05)。Logistic回归分析显示BMI、血尿酸、TG为T2DM患者发生NAFLD的独立危险因素(P<0.05)。结论血尿酸、TG、BMI与老年T2DM患者发生NAFLD存在密切的独立相关性,临床中应重视对老年T2DM患者血尿酸的控制,从而减少NAFLD的发生。
Objective To investigate the relationship between occurrence of nonalcoholic fatty liver disease(NAFLD)and serum uric acid level in patients with type 2 diabetes mellitus(T2DM).Methods A total of 225 elderly patients with T2DM,over 60 years old,admitted to the First Affiliated Hospital of Zhengzhou University from December 2017 to August 2018 were selected as research objects.And their clinical data were retrospectively analyzed.Among them,122 patients with NAFLD were allocated into DN group,and 103 patients without NAFLD were set as DM group.Age,body mass index(BMI),serum uric acid,total bilirubin(TBIL),direct bilirubin(BILD),indirect bilirubin(IBLD),total bile acid(TBA),alanine aminotransferase(ALT),aspartate aminotransferase(AST),glutamyl transpeptidase(GGT),triglyceride(TG),total cholesterol(TCHO),low density lipoprotein-cholesterol(LDL-C),high density lipoprotein-cholesterol(HDL-C),glycated hemoglobin(HbA1C)of all patients were recorded and analyzed.Results The levels of uric acid,ALT,AST,GGT,BMI and TG in DN group were significantly higher than those of DM group,however,the age and course of disease of DN group were significantly lower than those of DM group,and the difference was statistically significant(P<0.05).Logistic regression analysis showed that BMI,blood uric acid and TG were independent risk factors of occurrence of NAFLD in elderly T2DM patients(P<0.05).Conclusions There is a close independent correlation of serum uric acid,TG and BMI with NAFLD in elderly T2DM patients.It is necessary to focus on the control of blood uric acid in elderly patients with T2DM to reduce the occurrence rate of NAFLD.
作者
杨晶晶
李华
李天艺
冯明
吴聪
李如男
Yang Jingjing;Li Hua;Li Tianyi;Feng Ming;Wu Cong;Li Runan(Department of Senile Endocrinology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中国实用医刊》
2019年第9期23-25,共3页
Chinese Journal of Practical Medicine
关键词
血尿酸
老年
2型糖尿病
非酒精性脂肪肝
Blood uric acid
Elderly
Type 2 diabetes mellitus
Nonalcoholic fatty liver