槐杞黄颗粒联合布地奈德混悬液治疗儿童支气管哮喘效果观察

Effects of Huaiqihuang granule combined with budesonide suspension on children with bronchial asthma

目的探讨槐杞黄颗粒联合布地奈德混悬液治疗儿童支气管哮喘的临床效果。方法选取运城市中心医院2016年5月至2018年1月收治的支气管哮喘患儿87例,按照随机数字表法分为两组,对照组43例给予雾化吸入布地奈德混悬液治疗,观察组44例给予布地奈德混悬液雾化吸入联合槐杞黄颗粒治疗,观察比较两组临床治疗效果及治疗前后肺功能各指标[用力肺活量(FVC)、第1秒用力呼气量占预计值百分比(FEV1%)、用力呼气峰流速(PEF)]、血清T细胞亚群各指标(CD8^+、CD4^+、CD3^+)、血清白细胞三烯D4(LTD4)、基质金属蛋白酶抑制剂-1(TIMP-1)、γ-干扰素(IFN-γ)水平变化情况,并统计两组不良反应发生情况。结果①临床疗效:观察组治疗总有效率为90.91%(40/44),高于对照组的74.42%(32/43),P<0.05;②肺功能:治疗后3个月,观察组FVC、FEV1%及PEF高于对照组(P<0.05);③T淋巴细胞亚群:治疗后3个月,观察组血清CD4^+、CD3^+水平高于对照组,血清CD8+水平低于对照组(P<0.05);④血清学指标:治疗后3个月,观察组血清LTD4、TIMP-1水平低于对照组,血清IFN-γ水平高于对照组(P<0.05);⑤不良反应:观察组不良反应发生率为11.36%(5/44),对照组为9.30%(4/43),两组比较差异未见统计学意义(P>0.05)。结论布地奈德混悬液联合槐杞黄颗粒可改善支气管哮喘患儿的血清IFN-γ、LTD4、TIMP-1水平,增强其机体免疫功能,疗效确切,安全性高,有助于患儿肺功能的恢复。

Objective To investigate the application effect of Huaiqihuang granule combined with budesonide suspension on children with bronchial asthma.Methods A total of 87 children with bronchial asthma treated in Yuncheng Central Hospital from May 2016 to January 2018 were selected.And they were divided into two groups according to the random number table method.Forty-three patients in control group were treated with budesonide suspension,while 44 patients in observation group were treated with budesonide suspension inhalation combined with Huaiqihuang granules.The clinical therapeutic effect,all indicators of lung function,including forced vital capacity(FVC),percentage of forced expiratory volume of 1 second on predicted value(FEV1%),and forced expiratory peak flow rate(PEF),the indexes of serum T cell subsets(CD8^+,CD4^+,CD3^+),serum leukotriene D4(LTD4),matrix metalloproteinase inhibitor-1(TIMP-1)and interferon-γ(IFN-γ)were compared between the two groups before and after treatment.The occurrence of adverse effects of two groups was recorded.Results①The total effective rate of observation group was 90.91%(40/44),which was higher than 74.42%(32/43)of control group(P<0.05).②The FVC,FEV1%and PEF in observation group were higher than those in control group 3 months after treatment(P<0.05).③The serum levels of CD4^+and CD3^+in observation group were higher than those in control group 3 months after treatment,and the serum level of CD8+was lower than that in control group(P<0.05).④The serum levels of LTD4 and TIMP-1 of observation group were lower than those of control group 3 months after treatment,and the level of serum IFN-γwas higher than that of control group(P<0.05).⑤The incidence of adverse reactions in observation group was 11.36%(5/44),while it was 9.30%(4/43)in control group,and there was no significant difference between the two groups(P>0.05).Conclusions Budesonide suspension combined with Huaiqihuang granule can improve the levels of serum IFN-γ,LTD4 and TIMP-1,and enhance the immune function in children with bronchial asthma.It is effective and safe,and beneficial to restoring the lung function of the children.