麻杏石甘汤联合止嗽散加减治疗急性支气管炎(风热犯肺证)的效果及对炎性因子的影响

Effect of Maxing Shigan decoction combined with Zhisou powder on acute bronchitis(wind-heat invading lung syndrome) and its influence on inflammatory factors

目的探讨麻杏石甘汤联合止嗽散对急性支气管炎(风热犯肺证)的治疗效果及对炎性因子的影响。方法选择我院2015年7月至2018年7月收治的118例急性支气管炎(风热犯肺证)患者为研究对象,采用随机分组方式将患者分为对照组(n=59)和观察组(n=59)。对照组患者常规应用太极急支糖浆剂进行治疗,观察组患者应用麻杏石甘汤联合止嗽散加减治疗。比较两组患者的临床治疗效果、血常规指标及炎性因子水平。结果除舌苔薄黄外,观察组患者在治疗后其他的中医临床证候单项积分显著低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组患者的退热时间、主要临床症状积分及次要临床症状积分均显著优于对照组,差异具有统计学意义(P<0.05)。治疗后,除淋巴细胞百分比、红细胞、血红蛋白及血小板计数外,观察组患者的白细胞计数、中性粒细胞百分比均显著低于对照组,差异具有统计学意义(P<0.05)。观察组患者治疗后E-ICR及hs-CRP水平均显著低于对照组,差异有统计学意义(P<0.05)。结论麻杏石甘汤联合止嗽散加减治疗急性支气管炎(风热犯肺证)效果显著,其可明显缓解患者的临床症状,降低中医证候积分,改善血常规指标,减轻患者体内炎性状态,值得临床推广应用。

Objective To explore the effect of Maxing Shigan decoction combined with Zhisou powder on acute bronchitis (wind-heat invading lung syndrome) and its influence on inflammatory factors. Methods One hundred and eighteen patients with acute bronchitis (wind-heat invading lung syndrome) admitted in our hospital from July 2015 to July 2018 were selected as study objects and the patients were divided into control group (n=59) and observation group (n=59) by random grouping method. The patients in the control group were treated with Taiji acute bronchitis syrup routinely. The patients in the observation group were treated with Maxing Shigan decoction combined with Zhisou powder. The clinical therapeutic effects, the levels of blood routine indexes and inflammatory factors were compared between the two groups. Results Except for the thin yellow tongue coating, the scores of other TCM clinical symptoms in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the antipyretic time, the scores of main clinical symptoms and secondary clinical symptoms in the observation group were significantly better than those in the control group (P<0.05). After treatment, except for lymphocyte percentage, erythrocyte, hemoglobin and platelet count, the white blood cell count and neutrophil percentage in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the E-ICR and the level of hs-CRP in the observation group were significantly lower than those in the control group (P<0.05). Conclusion Maxing Shigan decoction combined with Zhisou powder has a remarkable effect in the treatment of acute bronchitis (wind-heat invading lung syndrome). It can obviously relieve the clinical symptoms, reduce the scores of TCM syndromes, improve blood routine indexes, and alleviate inflammatory state of patients. It is worthy of clinical promotion and application.