小型四极杆质量分析器的设计与性能测试

Design and Performance Analysis of A Miniature Quadrupole Mass Analyzer

设计了一款直径6mm、长度115mm的圆柱形小型四极杆质量分析器,基于此搭建了小型四极杆质谱仪,并与气相色谱仪联用。对此仪器的质量数范围、灵敏度、定量分析重复性及定性分析能力等指标的测试表明,在保证单位质量分辨的条件下,此小型四极杆质量分析器最大质量数超过500Th。此小型四极杆质谱仪对八氟氖(1ng)定量重复性相对标准偏差(RSD)优于3%,甲基苯丙胺质量在0.1~0.001μg范围内与质谱信号强度之间的关系为y=3.19662×10^7x^1.24606(R^2=0.998),纳克量级的16种常见毒品均能准确定性。更宽质量数范围的四极杆质量分析器与离子泵的组合,有望增强小型四极杆质谱仪在现场应急、毒品打击、军事反恐和航空航天等领域的应用。

For the past two decades, gas chromatography-mass spectrometry (GC-MS), the "gold standard" method, was developed rapidly in terms of the analysis and detection. Among them, the miniaturization of the ion trap mass analyzer developed rapidly, while the quadrupole mass analyzer was relatively slow due to its maximum mass range with the low level. In this work, a small quadrupole mass analyzer with a diameter of 6 mm and a length of 115 mm was designed. Based on this, a small quadrupole mass spectrometer was built and combined with gas chromatography. The test results of mass range, sensitivity, quantitative repeatability and qualitative ability of the instrument proved that the maximum mass range of the miniature quadrupole mass analyzer was more than 500 Th under the unit mass resolution. Based on this miniature quadrupole mass analyzer, the RSD of quantitative reproducibility of perfluoronaphthalene (1 ng) was better than 3%. In the range of 0.1 μg to 0.001 μg, the methamphetamine indicated that the quality and the signal intensity were in the relationship of y =3.19662×10^7x^1.24606 (R^2=0.988). The 16 common drugs at ng level could be accurately identified. The combination of quadrupole mass analyzer and ion pump with wider mass range was expected to enhance the application of small quadrupole mass spectrometer in the field of emergency, drug attack, military counter-terrorism, aerospace and others.