中药复方防治血管性痴呆的实验研究进展

Progress of Experimental Research on TCM Compound Formula Treating and Preventing Vascular Dementia

血管性痴呆(VD)临床老年性常见病、多发病,是各种脑血管疾病导致的脑功能障碍而引起的获得性认知功能损害综合征,为脑卒中后常见的并发症。西医目前对本病尚无理想的疗法和药物,而中药复方能从多途径、多靶点、多层次、多系统对VD的发病机制进行干预,突显了中药复方防治VD的潜力和优势。近年来中药复方在防治VD的实验研究方面取得了巨大进展。从对胆碱能神经系统的调控、抑制β-淀粉样蛋白及Tau蛋白过度磷酸化、拮抗氧化应激反应、抑制炎症反应、拮抗神经元凋亡、改善突触可塑性6方面综述中药复方防治血管性痴呆的实验研究进展,彰显了中药复方在防治血管性痴呆方面的强大优势。

Vascular dementia(VD) is a common and frequently-occurring disease in the elderly.It is an acquired cognitive impairment syndrome due to brain dysfunction caused by cerebrovascular diseases.It is also a common complication after stroke.Western medicine currently has no ideal therapies and medications for this disease,whereas TCM compound formula can intervene the pathogenesis of VD from multiple pathways,multiple targets,multiple levels and multiple systems,which highlights the potential and advantages of TCM compound formula in the prevention and treatment of VD.In recent years,TCM compound formula has made great progress in the experimental research on prevention and treatment of VD.This study reviewed the progress of TCM compound formula treating and preventing VD,in terms of regulating cholinergic nervous system,inhibiting β-amyloid and Tau protein hyperphosphorylation,antagonizing oxidative stress,reducing inflammatory response,resisting neuronal apoptosis,and improving synaptic plasticity.