重视胃肠间质瘤的诊断和治疗

Pay Attention to Diagnosis and Treatment of Gastrointestinal Stromal Tumors

胃肠间质瘤(GIST)是胃肠道最常见的间叶源性肿瘤,受体酪氨酸激酶抑制剂甲磺酸伊马替尼用于GIST的治疗取得卓著疗效,GIST因此成为实体肿瘤靶向药物治疗最成功的范例。GIST在病理诊断、内镜和影像学诊断、手术原则、药物治疗等诸多方面与其他胃肠道肿瘤存在很大区别。多学科协作诊疗模式在GIST的诊断和治疗中发挥重要作用。当代医学已进入规范化、个体化和分子水平精准诊疗的新时代,临床医师尤其是从事胃肠肿瘤专业的医师应重视和规范GIST的诊断和治疗,并将从GIST诊疗中获得的经验运用到精准医学的临床实践中去。

Gastrointestinal stromal tumor(GIST)is the most common mesenchymal tumor in the gastrointestinal tract.The receptor tyrosine kinase inhibitor imatinib mesylate is used for the standard treatment of GIST and has achieved remarkable results.Thus,GIST has become the most successful model for targeted therapy of solid tumors.GIST is quite different from other gastrointestinal tumors in pathological diagnosis,endoscopic and imaging diagnosis,surgical principles and drug treatment.Multidisciplinary collaborative model plays an important role in the diagnosis and treatment of GIST.Contemporary medicine has entered a new era of standardized,individualized and precise diagnosis and treatment at molecular level.Clinicians,especially those engaged in gastrointestinal tumors,should pay attention to and standardize the diagnosis and treatment of GIST,and apply the experience gained from GIST to the clinical practice of precision medicine.