脑血管支架置入术后再狭窄的影响因素分析

Factors that lead to restenosis after cerebrovascular stent implantation

目的观察脑血管支架置入术后再狭窄的情况并分析其影响因素。方法回顾性分析100例行脑血管支架置入术患者的临床资料,术后随访1年。患者根据术后是否出现再狭窄分为再狭窄组和无再狭窄组,分析影响脑血管支架置入术后再狭窄的影响因素。结果术后随访1年,9%(9/100)患者出现再狭窄。两组患者年龄、吸烟、糖尿病、冠心病、高血压、高血脂及术后按规律使用抗凝药物的比例比较,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,吸烟(OR=8.304)、糖尿病(OR=5.082)、冠心病(OR=5.269)、高血压(OR=7.914)及高血脂(OR=4.971)为脑血管支架置入术后再狭窄的危险因素(P<0.05)。结论吸烟、糖尿病、冠心病、高血压及高血脂会增加脑血管支架置入术后再狭窄的风险,应在临床中加以相应的监控。

Objective To examine the state of restenosis after cerebrovascular stent implantation and the possible factors that contribute to the disease. Methods Firstly, the clinical data of 100 patients having undergone cerebrovascular stent implantation were subjected to retrospective analysis. Follow-ups were then conducted for one year. Then subjects were then divided into two groups, namely, restenosis group (in which restenosis was identified) and no restenosis group (in which restenosis was not found after operation). The factors that gave rise to the disease were lastly examined. Results 9%(9/100) of the patients were found to have vascular restenosis during the follow-ups. Statistically significant differences were found between the two groups in age, the rates of smoking habit, incidence of diabetes, incidence of coronary heart disease, incidence of hypertension, incidence of hyperlipemia and regular anticoagulant medication ( P <0.05). Multivariate logistic regression analysis showed that smoking ( OR =8.304), diabetes ( OR =5.082), coronary heart disease ( OR =5.269), hypertension ( OR =7.914), and hyperlipemia ( OR =4.971) were the risk factors that contributed to restenosis after surgery of cerebrovascular stent implantation ( P <0.05). Conclusions Smoking, diabetes, coronary heart disease, hypertension, and hyperlipemia increase the occurrence of restenosis after cerebrovascular stent implantation and therefore should be closely monitored and treated in clinical practice.