摘要
微小RNA(miR)是心血管疾病发生发展的重要调控因子。其中,miR-34a因广泛参与心血管疾病的病理生理过程成为目前研究热点。在冠状动脉粥样硬化性心脏病等心血管疾病中均存在miR-34a的异常表达。本文就miR-34a对心血管疾病的作用及其机制研究进展进行综述,为寻求心血管疾病标志物及治疗靶点提供新思路。
MicroRNA( miR) have been considered as the important regulators in both physiological and disease contexts ,among which miR-34a has drawn great attention as its multiple functions in cardiovascular disease. It is reported that miR-34a is either upregulated or downregulated in atherosclerotic cardiovascular diseases, etc. This article reviews both the roles and mechanisms of miR-34a in cardiovascular diseases, aiming to provide new ideas for further researches on biomarkers and treatment target of cardiovascular disease.
作者
李晓伟
奉淑君
周凤华
靳文
赵一俏
LI Xiaowei;FENG Shujun;ZHOU Fenghua;JIN Wen;ZHAO Yiqiao(University of South China,Hengyang,Hunan 421001 ,China;Department of Cardiology,Guangdong Second,Provincial General Hospital,University of South China,Guangzhou,Guangdong 510317 ,China;Department of Cardiology,the First People's Hospital of Chenzhou,University of South China,Chenzhou,Hunan 423000,China;School of Traditional Chinese Medicine,Southern Medical University,Guangzhou,Guangdong 510515 ,China)
出处
《中国动脉硬化杂志》
CAS
2019年第7期624-628,共5页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金青年科学基金(81202951)
广东省自然科学基金(2016A030313853)
中国中青年临床研究基金(2017-CCA-VG-016)
“互联网+专家团队”驱动的高血压分级诊疗模式示范应用(2018-TG-03)
