摘要
环状RNA(circular RNA,circRNA)是一类新型的非编码RNA,以共价键形成闭合环形结构,较线性RNA更稳定。CircRNA作为在真核生物中的高丰度RNA,参与调控靶基因表达,与多种疾病有着密切联系,有作为临床诊断及预后标志物的潜在应用价值。该文概述了circRNA分子的分类、生物学功能(包括作为微RNA分子海绵、调控基因转录、调节RNA结合蛋白以及其潜在的翻译功能),并就近年来circRNA在类风湿关节炎中的最新研究进展作一综述。
Circular RNAs(circRNAs) are a novel class of non-coding RNAs, which are more stable than linear RNAs for their closed circular structure by covalent bond. CircRNAs exist in a large variety of cells and regulate the expressions of target genes. Moreover, circRNAs are closely related to various diseases and have a potential value as biomarkers and prognostic markers clinically. In this article, the classification and biological functions of circRNA molecules(including being as microRNA sponges, regulating gene transcription, regulating RNA binding protein and the potential translation function) are summarized, and the latest research progress of circRNAs in rheumatoid arthritis is reviewed.
作者
陈一丹
林桑
刘欢
尹耕
CHEN Yidan;LIN Sang;LIU Huan;YIN Geng(Department of Rheumatology and Immunology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China)
出处
《华西医学》
CAS
2019年第6期693-697,共5页
West China Medical Journal
基金
国家自然科学基金(81172869,30901339)
四川省科技厅应用基础重点项目(2017JY0025,2016JY0021)