胃炎宁颗粒质量标准研究

Study on the Quality Standard of Weiyanning Granules

目的:完善并提升胃炎宁颗粒的质量标准。方法:采用薄层色谱法(TLC)对薏苡仁、甘草进行定性鉴别;采用高效液相色谱法对甘草主要活性成分甘草苷和甘草酸的含量进行测定。结果:薏苡仁与对照药材和对照提取物,甘草与甘草对照药材斑点清晰,分离度良好,阴性样品无干扰;甘草苷和甘草酸分别在0.025 4~1.268 2 mg和0.031 8~1.591 3 mg质量范围内与峰面积积分呈良好的线性关系,平均回收率分别为100.92%和100.69%(n=6)。结论:建立的质量控制方法操作简单、灵敏度高、重现性好、专属性强,可为有效控制胃炎宁颗粒的质量提供参考依据。

Objective: To improve the quality standard of weiyanning granules. Methods: Coix seed and liquorice root were identified by TLC. The contents of glycyrrhizin and glycyrrhizic acid were determined by HPLC. Results: Coix seed and control material and control extract, licorice and licorice control material spots clear, separation degree is good, negative without interference;There was a good linear relationship between glycyrrhizin and glycyrrhizin in the range of 0. 025 4~1. 268 2mg and 0. 031 8~1. 591 3mg, respectively. and the average recovery was 100. 92% and 100.69%, respectively (n=6). Conclusion : This method has the advantages of simple operation, high sensitivity, good reproducibility and high specificity.