食管鳞癌PBMC中lncRNA-SNHG20的表达及临床意义

Expression of lncRNA-SNHG20 in peripheral blood mononuclear cells of patients with esophageal squamous cell carcinoma and its clinical significance

目的探究长链非编码RNASNHG20在食管鳞状细胞癌患者外周血单个核细胞中的表达及临床意义。方法择取2018年1月至2018年6月郑州大学第二附属医院收治的食管鳞状细胞癌患者40名作为研究组,另择取同期健康体检者30名作为对照组,采用实时定量PCR检测两组患者外周血单个核细胞中SNHG20的相对表达量,比较两组结果差异,分析其在食管鳞癌中的临床意义。结果研究组外周血单个核细胞中SNHG20表达量检测结果低于对照组,差异具有统计学意义(P<0.05),且与食管癌肿瘤分化程度、淋巴结浸润、是否远端转移和TNM分期密切相关。结论食管鳞状细胞癌患者外周血单个核细胞中SNHG20表达变化与其病情之间存在紧密联系,可作为一个潜在的无创性分子指标。

Objective To explore the expression and clinical significance of lncRNA SNHG20 in peripheral blood mononuclear cells of patients with esophageal squamous cell carcinoma. Methods Select 40 patients with esophageal squamous carcinoma as a research team between January 2018 and June 2018 from the Second Affiliated Hospital of Zhengzhou University,the other 30 healthy people as a control. Using real-time quantitative PCR detect the SNHG20 expression quantity in the PBMC of two groups of patients. Compare the difference of results between the two groups and analyze its clinical significance in esophageal cancer. Results The detection results of SNHG20 expression in PBMC of the study group were all lower than those of the control group(P<0.05), which was closely related to the degree of esophageal cancer tumor differentiation,lymph node infiltration, whether distant metastasis and TNM stage.Conclusion The changes of SNHG20 expression in PBMC of patients with esophageal squamous cell carcinoma are closely related to their disease.