ⅡB期宫颈癌不同治疗方案的研究进展

Research progress on the different treatment options for stage ⅡB cervical cancer

子宫颈癌是重要的全球公共卫生问题,在我国发病逐渐趋于年轻化。ⅡB期宫颈癌同步放化疗在降低局部复发率、提高无进展生存率和总生存率、改善预后等方面具有明显优势。术前同期放化疗+手术治疗可有效缩小局部病灶,增加手术切除机会,且未增加手术难度及术后并发症发生率,同时避免了根治性放疗引起的各种近期、远期并发症。新辅助化疗争取进行根治性手术的机会,利用手术来消除放化疗抵抗性病灶,延长患者的无瘤生存时间,提高患者的生存质量。术前适量放疗还可以保持女性阴道的生理功能,避免了根治性放疗造成的各种并发症。

Cervical cancer is an important global public health problem,and its incidence tends to be younger in China. Compared with stage ⅡB cervical cancer,concurrent chemoradiotherapy has obvious advantages in reducing local recurrence rate,improving progression free survival rate,overall survival rate,and improving prognosis. Concurrent chemoradiotherapy and surgical treatment can effectively reduce local lesions and increase the opportunity for surgical resection. Synchronous radiotherapy and chemotherapy do not increase the difficulty of operation and postoperative complications. At the same time,all kinds of shortterm and long-term complications caused by radical radiotherapy are avoided. The new adjuvant chemotherapy will strive for radical surgery,using radical surgery to eliminate the focus of radiotherapy and chemotherapy,improve the patient’s survival time and improve the patient’s quality of life. Preoperative radiotherapy can also maintain the physiological function of the vagina and avoid various complications caused by the amount of radical radiotherapy.