射干麻黄汤对慢性支气管炎急性发作老年患者血清IL-6、PCT、hs-CRP的影响

Analysis of the Treatment of PCT Patients with Inflammatory Conditions and Sheganmahuang Decoction in Acute Attack of Senile Chronic Bronchitis

目的:观察射干麻黄汤对慢性支气管炎急性发作老年患者的疗效及血清IL-6(白细胞介素6,interleukin 6,IL-6)、PCT(降钙素原,procalcitonin)、hs-CRP(超敏C反应蛋白,hypersensitive C-reactive protein,hs-CRP)的影响。方法:70例老年慢性支气管炎急性发作患者,随机分为2组,各35例。对照组采用常规西药治疗,研究组在对照组治疗的基础上给予射干麻黄汤进行治疗。治疗10d后,对两组患者的治疗效果以及血清IL-6、hs-CRP、PCT水平进行分析比较。结果:治疗后,研究组治疗总有效率(97.14%)明显高于对照组(77.14%),差异有统计学意义(P<0.05)。研究组血清IL-6、hs-CRP、PCT水平明显低于对照组,差异有统计学意义(P<0.05)。研究组治疗后的不良反应发生率(5.71%)高于对照组(8.56%),两组比较无统计学差异(P>0.05)。结论:射干麻黄汤治疗慢性支气管炎急性发作患者,能够有效提高疗效,降低血清IL-6、hs-CRP、PCT水平。

Objective To study the effect of Shegan Mahuang Decoction on senile patients with acute exacerbation of chronic bronchitis and the influence of serum IL-6, PCT and hs-CRP. Methods 60 patients with acute exacerbation of chronic bronchitis were selected from November 2015 to January 2017. All patients were randomly divided into study group and control group according to the method of random number table. Patients in the control group were treated with routine western medicine, while patients in the study group were treated with Shegan Mahuang Decoction on the basis of the treatment methods in the control group. The therapeutic effects and the levels of IL-6, hs-CRP and PCT were compared between the two groups.Results After treatment, the total effective rate of the study group ( 97.14%) was significantly higher than that of the control group ( 77.14%), The difference was statistically significant ( P < 0.05 ). After treatment, the levels of IL-6, hs-CRP and PCT in the study group were significantly lower than those in the control group ( P < 0.05 ). The incidence of adverse reactions in the study group ( 5.71%) was significantly higher than that in the control group ( 8.56%), There was no significant difference between the two groups ( P > 0.05 ).Conclusion The treatment of Shegan Mahuang Decoction for acute attack of chronic bronchitis can effectively improve the curative effect of patients, improve the levels of IL-6, hs-CRP, PCT, and is worthy of clinical promotion.