摘要
皮肤是维持机体内环境稳定,抵御外界环境刺激和病原菌入侵的重要屏障,同时也是烧创伤过程中最容易受损的器官。大面积皮肤缺损,皮源有限,无法自行恢复原有的结构和功能,而且易引起诸多严重并发症,直接危及患者生命。皮肤替代模式着力于研究修复、替代皮肤缺损的天然或人工合成的类皮肤结构,经历了从传统敷料到组织工程皮肤的演变。本文就皮肤替代模式的研究现状及发展前景进行综述。
The skin is an essential barrier to maintain the homeostasis and resists external stimuli and pathogen.It is the most vulnerable organ in the events of burns and injuries as well.Large skin defect usually causes various serious complications,even directly endangers the patient′s life.It is impossible for large skin defect area to restore original structure and function due to limited skin resources.The skin replacement model focuses on the research and development of repairing and replacing of skin defects,utilizing natural or artificial skin-like tissue.This strategy has experienced the transition from traditional dressing to tissue engineering skin.This review summarizes the research status and prospects of the skin replacement model.
作者
卫裴
罗鹏飞
夏照帆
Wei Pei;Luo Pengfei;Xia Zhaofan(Department of Burns Surgery,Fujian Medical University Union Hospital,Fuzhou 350001,China;Burn Institute of PLA,Department of Burns and Trauma Surgery,Naval Military Medical University,Shanghai 200433,China)
出处
《中华损伤与修复杂志（电子版）》
CAS
2019年第3期161-165,共5页
Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)
基金
国家自然科学基金(81772076,81120108015)
“十三五”科技计划(AWS14C001,201502028,AWS11J008)
国家“973”计划项目(2012CB518100)
国家/上海市重点学科建设计划
关键词
皮肤
人工
伤口愈合
生物敷料
皮肤移植
组织工程
Skin,artificial
Wound healing
Biological dressings
Skin transplantation
Tissue engineering
