新疆维吾尔自治区汉、维吾尔和哈萨克族人群的缺血性心血管病10年发病危险度差异性分析

Comparison on the 10 years risk for ischemic cardiovascular disease among Han,Uygur,Kazak population from Xinjiang Uygur Autonomous Region

目的探讨新疆维吾尔自治区汉、维吾尔和哈萨克族人群缺血性心血管病10年发病危险度的差异。方法2007年10月至2010年10月在新疆维吾尔自治区7个市或地区,采用四阶段分层整群抽样方法,抽取汉、维吾尔和哈萨克族35岁及以上成年人14 618名作为研究对象,其中汉族5 757名,维吾尔族4 767名,哈萨克族4 094名。采用国人缺血性心血管病10年发病危险评估表计算缺血性心血管病10年发病危险度,并对3个民族的危险度进行比较。结果(1)汉、维吾尔和哈萨克族人群在年龄、体重指数、收缩压、舒张压、空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、吸烟史和饮酒史方面差异均有统计学意义(P均<0.001)。(2)不同性别和年龄段(35~39、40~44、45~49、50~54、55~59和≥60岁)汉、维吾尔和哈萨克族人群的缺血性心血管病10年发病危险度差异均有统计学意义(P均<0.001)。(3)汉、维吾尔和哈萨克族不同性别间的缺血性心血管病10年发病危险度10%~20%和>20%比例差异均有统计学意义(P值分别为0.013和<0.001)。汉、维吾尔和哈萨克族不同性别间的缺血性心血管病10年发病危险度<5%和5%~9%比例差异均无统计学意义(P均>0.05)。(4)在缺血性心血管病10年发病危险度≥10%人群中,男性和女性汉、维吾尔和哈萨克族成年人间的糖尿病、高血压、吸烟、高甘油三酯血症和肥胖检出率差异均有统计学意义(P<0.01或0.05);男性汉、维吾尔和哈萨克族成年人间的高胆固醇血症检出率差异有统计学意义(P<0.001);男性和女性汉、维吾尔和哈萨克族成年人间的高低密度脂蛋白胆固醇血症和低高密度脂蛋白胆固醇血症检出率差异均无统计学意义(P均>0.05)。结论新疆维吾尔自治区35岁及以上汉、维吾尔和哈萨克族成年人的缺血性心血管病10年发病危险度有明显的性别和年龄差异。

Objective To compare the 10 years risk for ischemic cardiovascular disease among Han,Uygur,Kazak nationality residents of Xinjiang Uygur Autonomous Region.Methods From October 2007 to October 2010,14 618 adult (aged ≥35 years) Han (n=5 757),Uygur (n=4 767) and Kazak (n=4 094) residents were selected to join this study through the four-stage stratified cluster sampling method from 7 cities and regions of Xinjiang Uygur Autonomous Region.The 10 years risk for ischemic cardiovascular disease was calculated according to the 10 years ischemic cardiovascular disease risk assessment form modified with Chinese characteristics and compared among the residents of 3 nationalities.Results (1) There were significant differences in age,body mass index,systolic blood pressure,diastolic blood pressure,fasting blood glucose,triglycerides,total cholesterol,low-density lipoprotein,high-density lipoprotein cholesterol,smoking history,and drinking history among Han,Uygur,Kazak nationality population (all P< 0.001).(2) There were significant differences in 10 years risk for ischemic cardiovascular disease between different gender and age group including 35-39,40-44,45-49,50-54,55-59,and ≥60 years old between Han,Uygur,Kazak nationality population (all P<0.001).(3) There were significant differences in rates of 10%-20% and>20% of 10 years risk for ischemic cardiovascular disease between different gender in Han,Uygur,Kazak nationality population (P values were 0.013 and <0.001,respectively).There were no significant differences in rates of <5% and 5%-9% of 10 years risk for ischemic cardiovascular disease between different gender in Han,Uygur,Kazak nationality population (all P>0.05).(4) There were significant differences in detection rates of diabetes,hypertension,smoking,hypertriglyceridemia,and obesity in male and female Han,Uygur,Kazak nationality population with 10 years risk for ischemic cardiovascular disease ≥10%(P<0.01 or 0.05).Meanwhile,there was significant difference in detection rates of hypercholesteremia in male Han,Uygur,Kazak nationality adults(P<0.001).There were no significant differences in detection rates of elevated low density lipoprotein cholesterol and reduced high density lipoprotein cholesterol in male and female Han,Uygur,Kazak nationality adults (all P>0.05).Conclusion There are gender and age differences in the 10 years risk for ischemic cardiovascular disease in ≥35 years old Han,Uygur,Kazak nationality adults from Xinjiang Uygur Autonomous Region.