儿童细菌性脑膜炎抗生素的规范治疗

Rational antimicrobial therapy for bacterial meningitis in children

细菌性脑膜炎是儿童常见中枢神经系统感染性疾病,及时、有效、足量、足疗程的抗生素治疗可减少病死率及后遗症发生率,改善预后。根据发病年龄、临床情况、耐药现状合理选择抗生素进行经验性治疗,及时获取病原学证据进行针对性的目标治疗,利用抗生素药动学/药效学理论优化治疗方案,加强药学监护,对于有效控制感染、清除病原、改善预后、控制细菌耐药具有重要临床意义。

Bacterial meningitis is a common infectious disease of central nervous system in children.Timely, effective, adequate, and sufficient course of antibiotics therapy is the key to reduce mortality rate and incidence of sequelae, and improve prognosis.Starting reasonable empirical antimicrobial therapy according to the onset ages, clinical situation, and drug resistance status, and obtaining the evidence of pathogens timely to start effectively target treatment, optimizing the therapeutic scheme based on pharmacokinetic/pharmacodynamic theory, strengthening pharmaceutical care, play vital roles in effectively controlling infection and eliminating pathogens, improving prognosis and reducing bacterial drug resistance.