摘要
嵌合型抗原受体修饰T (chimeric antigen receptor modified T,CAR-T)细胞疗法是肿瘤免疫治疗的重要手段之一,CAR-T细胞的靶向性、杀伤活性、增殖性和持久性较常规T细胞明显提高,并且经过不断的改进演变,其在血液系统肿瘤治疗中取得了巨大的成效,受到广泛的关注。然而,其治疗过程中出现的神经毒性,也称CAR-T细胞相关脑病综合征(CAR-T cell relevant encephalopathy syndrome,CRES),影响了CAR-T疗法的临床应用。探索CRES的发病机制及其高风险因素、寻找相应的处理策略,对预防和治疗CRES具有重要意义。本文以CD19-CAR-T 细胞治疗为例,就CRES的发病症状、发病机制、高风险因素及应对策略作一综述,为临床治疗提供参考。
Chimeric antigen receptor modified T (CAR-T) cell therapy is one of the important methods of tumor immunotherapy. The targeting, killing, proliferation and persistence of CAR-T cells are significantly enhanced than that of conventional T cells. After continuous improvement and evolution, CAR-T cell treatment has achieved excellent progress in hematological tumors and has received extensive attention. However, neurotoxicity arising from the treatment, also known as CAR-T cell relevant encephalopathy syndrome (CRES), has affected its clinical application. Exploring the pathogenesis of CRES and high-risk factors, and finding appropriate strategies is therefore critical for the prevention and treatment of CRES. Here, we take CD19-CAR-T cell treatment as example to review the symptoms and pathogenesis of CRES, discuss high-risk factors as well as coping strategies, in an effort to provide a reference for clinical treatment.
作者
刘兆楠
韩为东
蒋敬庭
LIU Zhaonan;HAN Weidong;JIANG Jingting(Department of Tumor Biological Treatment, the Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu, China;Institute of Cell Therapy, Soochow University, Changzhou 213003, Jiangsu,China;Institute of Basic Medicine, General Hospital of PLA, Beijing 100853, China)
出处
《中国肿瘤生物治疗杂志》
CAS
CSCD
北大核心
2019年第6期617-622,共6页
Chinese Journal of Cancer Biotherapy
基金
国家重点研发资助项目(No.2018YFC1313400)
国家科技支撑计划资助项目(No.2015BAI12B12)
国家自然科学基金海外及港澳学者合作研究基金项目(No.31729001)
国家自然科学基金资助项目(No.31570877,31570908)
江苏省重点研发计划专项资金项目(No.BE2018645)~~
关键词
嵌合型抗原受体修饰T细胞
神经毒性
CAR-T细胞相关脑病综合征
应对策略
chimeric antigen receptor modified T (CAR-T) cell
neurotoxicity CAR-T cell relevant encephalopathy syndrome (CRES)
coping strategies