HIV感染者治疗期间焦虑抑郁情况的纵向研究

Longitudinal study of anxiety and depression during treatment of HIV-infected patients

目的探讨HIV感染者不同时间点焦虑、抑郁水平的动态变化趋势。方法选择深圳市某三级医院门诊的247例HIV感染者为研究对象,采用一般资料调查表、医院焦虑抑郁量表纵向测评HIV感染者服药前、服药3个月后、服药6个月后的焦虑、抑郁评分,采用重复测量方差分析探讨HIV感染者焦虑、抑郁水平及CD4^+ T淋巴细胞计数的时间效应。结果 HIV感染者服药前焦虑、抑郁评分分别为(19.04±2.34)分和(17.05±2.48)分,CD4^+ T淋巴细胞计数为(281.00±146.35)个/mm^3。服药后焦虑、抑郁水平均有所改善,CD4^+T淋巴细胞计数逐渐增高。重复测量方差分析结果显示,HIV感染者焦虑、抑郁评分及CD4^+ T淋巴细胞计数在不同时间点之间差异有统计学意义(F=11.33,P<0.001;F=11.68,P<0.001;F=156.02,P<0.001)。结论随着抗病毒药物服用时间的延长,HIV感染者焦虑、抑郁水平逐渐降低,应针对不同治疗时期,及时评估和实施相关干预。

Objective To investigate the dynamic trends of anxiety and depression levels in HIV-infected patients at different time points.Methods A total of 247 HIV-infected patients in outpatient department of a hospital were selected as subjects.General information questionnaire and Hospital Anxiety and Depression Scale were used to investigate anxiety and depression of HIV-infected patients before taking medicine,taking medicine for 3 months,taking medicine for 6 months.The scores of anxiety and depression in HIV-infected patients and CD4^+ T lymphocyte count were analyzed by repeated measurement analysis of variance to explore the temporal effects.Results Before taking medicine,the anxiety and depression scores of HIV-infected patients were(19.04±2.34) and(17.05±2.48),respectively.The CD4^+ T lymphocyte count was(281.00±146.35)/mm^3.The levels of anxiety and depression were improved,and the CD4^+ T lymphocyte counts gradually increased after taking medicine.Repeated measurement analysis of variance showed that the differences in scores of anxiety and depression and CD4^+ T lymphocyte count among HIV-infected patients were statistically significant at different time points(F=11.33,P<0.001;F=11.68,P<0.001;F=156.02,P<0.001).Conclusion With the prolongation of antiviral drugs,the levels of anxiety and depression in HIV-infected patients are gradually reduced.Targeted interventions should be evaluated and implemented in a timely manner for different treatment periods.