Suzuki偶联反应催化剂及其作用机理研究进展

Research Progress of Suzuki Cross-Coupling Reaction Catalyst and Its Action Mechanism

Suzuki偶联反应,是指在温和条件下,卤代苯与苯硼酸类化合物经钯催化剂作用发生交叉偶联,生成新C-C键的反应,其在药物研发与合成中具有重要的应用.钯基催化剂是Suzuki偶联反应的关键,开发低成本、新型高活性催化剂并探究其作用机理对于该反应的广泛应用具有重要意义.通过对钯基催化剂种类、应用范围及其可能的催化机理相关研究进行的分析,可为设计新型Suzuki偶联反应的钯基纳米催化剂提供有效信息.

Suzuki cross-coupling refers to the reaction,in which halobenzene and benzenic boric acid are catalyzed by palladium catalyst to generate a new C-C bond under mild conditions.Suzuki cross-coupling reaction plays a key role in drug development and synthesis.With palladium-based catalyst being the key factor of Suzuki coupling reaction,it is of great significance to develop a new type of catalyst with low cost and high activity,as well as to explore its catalytic mechanism.The aim of this paper is to review the types,application ranges and possible catalytic mechanism of palladium catalysts,which is helpful for the design of novel palladium-based nano-catalysts for Suzuki coupling reaction.