益肾颗粒制备工艺研究

Study on Preparation process of Yishen Granule

优化益肾颗粒最佳的成型工艺。采用正交试验设计,以辅料的种类、加入量、乙醇的浓度、干燥温度为影响因素,以颗粒的成型性、流动性、吸湿性为评价指标,优化颗粒成型工艺。最佳处方及制备工艺为浸膏:糊精:乳糖为1:1:1、乙醇的体积分数为65%,干燥温度60℃。颗粒剂制备工艺简单、稳定,质量可靠。

Taking the kind of subsidiary material, added amount, alcohol concentration and drying temperature as effective factors, and formation, fluidity and hydroscopicity of granule as evaluate index, the paper introduces the optimal formation technology to prepare the Yishen granule obtained by orthogonal method. As a result, the optimal ratio of extract, dextrin and lactose is 1:1:1, the volume fraction of wetting agent is 65% ethanol, and the dry temperature is 60℃. The preparation process is stable, feasible, and the quality of Yishen granule is reproducible.