痛风性关节炎病人血清免疫球蛋白水平与疼痛的相关性研究

A STUDY OF THE CORRELATION BETWEEN LEVELS OF SERUM IMMUNOGLOBULIN AND PAIN IN GOUTY ARTHRITIS PATIENTS

目的:分析痛风性关节炎(gouty arthritis,GA)病人血清免疫球蛋白及其亚型的变化以及与痛风活动程度的相关性。方法:收集中日友好医院2018年9月至2019年1月期间痛风性关节炎病人(GA组,n=101)和健康志愿者对照组(NC组,n=101)的临床资料及血清样本,采用免疫比浊法测定血清免疫球蛋白及其亚型水平,用SPSS统计软件对病人血清免疫球蛋白及其亚型与炎性因子、尿酸水平、疾病活动度等指标进行相关性分析。结果:GA病人血清IgA、IgM、IgE、C反应蛋白(reactive protein,CRP)水平与对照组相比显著升高(P<0.05);总IgG、IgG1、IgG3、IgG4水平与对照组相比显著降低(P<0.05)。GA病人急性期血清IgM、IgA、IgE、CRP水平、VAS评分与缓解期相比显著升高(P<0.05);相关性分析示:视觉模拟评分法(visual analogue scale,VAS)评分与血清IgE、IgM、CRP水平呈正相关(P<0.05),与尿酸(uric acid,UA)及其他所选实验室指标无显著相关性(P>0.05)。结论:GA病人血清IgM、IgA、IgE水平显著升高,可能参与了GA的发病。

Objective:This paper aims to analyze the changes of serum immunoglobulin and its subtypes in patients with gouty arthritis(GA)and the correlation between the levels of serum immunoglobulin(group GA,n=101)and the activity of gouty arthritis.Methods:Clinical data and serum samples of gouty arthri-tis patients and healthy volunteers(group NC,n=101)in China-Japan Friendship Hospital were collected from September 2018 to January 2019.The levels of serum immunoglobulin and its subtypes were mea-sured by immunoturbidimetry method.SPSS statistical software was used to compare the differences in immunoglobulin levels between the two groups and the correlations between the serum immuno-globulin and the disease activity were analyzed.Results:The levels of serum IgA,IgM,IgE and C reactive protein(CRP)in patients with GA were significantly higher than those in the control group(P<0.05),while the levels of total IgG,IgG1,IgG3 and IgG4 were signi cantly lower than those in the control group(P<0.05).The levels of serum IgM,IgA,IgE,CRP and VAS in patients with GA in acute stage were signi cantly higher than those in remission stage(P<0.05);correlation analysis showed that visual analogue scale(VAS)scores were positively correlated with serum IgE,IgM,CRP(P<0.05),but not with uric acid(UA)and other biomarkers(P>0.05).Conclusion:Serum IgM,IgA and IgE levels in patients with GA are signi cantly increased,and they may be involved in the pathogenesis of GA.