首发精神分裂症患者磁共振脑结构形态学研究

Brain morphology in patients with first-episode schizophrenia: a magnetic resonance imaging study

目的:探讨首发精神分裂症(FESZ)患者磁共振脑结构形态学变化。方法:分别采集86例FESZ患者(患者组)和86例健康人(对照组)的脑T1高分辨图像数据。采用FSL 5.0对数据进行基于体素的形态测量法(VBM)分析。结果:FSL-VBM显示,FESZ患者与对照组相比存在广泛的大脑灰质体积减小,包括中央前回、额上回、额中回、额下回、额内侧回、中央后回、顶下小叶、顶上小叶、缘上回、颞上回、颞中回、前扣带皮层、中扣带皮层及辅助运动区;小脑灰质体积增加(P<0.05, TFCE校正)。结论:FESZ患者在发病的早期阶段即可能存在广泛的脑结构形态学异常。

Objective To investigate the morphological changes of the brain structure in patients with first-episode schizophrenia using magnetic resonance imaging(MRI). Methods High-resolution T1-weighted MRI images of the brain in 86 patients with first-episode schizophrenia and 86 age-and gender-matched healthy controls were collected. FMRIB software library(FSL) 5.0 was used for voxel-based morphometry(VBM) analysis. Results FSL-VBM revealed that compared with normal controls, patients with first-episode schizophrenia had extensively grey matter lost in brain regions which included precentral gyrus, superior frontal gyrus, middle frontal gyrus, inferior frontal gyrus, medial frontal gyrus, postcentral gyrus, inferior parietal lobule, superior parietal lobule, supramarginal gyrus, superior temporal gyrus, middle temporal gyrus, anterior cingulate cortex, middle cingulate cortex and supplementary motor area, but increased grey matter volume in cerebellum(P<0.05, TFCE correction). Conclusion Patients with first-episode schizophrenia may have considerable brain morphological changes at the early stage.