复方丹参注射液联合常规西医治疗对早发型重度子痫前期孕妇病情及母婴结局的影响

Effect of compound Danshen injection combined with conventional western medicine treatment on disease condition,maternal and neonatal outcomes in early onset severe preeclampsia patients

目的:探讨复方丹参注射液联合常规西医治疗对早发型重度子痫前期(EOSPE)孕妇病情及母婴结局的影响。方法:收集2014年12月至2017年2月在广东医科大学附属中山陈星海医院产检并确诊EOSPE的孕妇60例,按随机数字表法分为观察组和对照组,每组30例。对照组患者接受常规西医治疗,观察组患者接受复方丹参注射液联合常规西医治疗,持续2周。比较两组患者超声子宫动脉血流参数、外周血血管内皮功能及凝血功能指标水平及母婴结局。结果:治疗2周后,观察组搏动指数(PI)、阻力指数(RI)、脐动脉血流阻抗值(S/D)、血清内皮素-1(ET-1)含量及外周血纤维蛋白原(Fib)、D-二聚体(D-D)水平低于对照组,血清一氧化氮(NO)含量高于对照组,凝血酶原时间(PT)和活化部分凝血活酶时间(APTT)长于对照组,差异均有统计学意义(均P<0.05)。观察组不良母婴结局(早产、产后出血、新生儿窒息等)发生率低于对照组(P<0.05)。结论:复方丹参注射液联合常规西医治疗EOSPE孕妇,可有效降低子宫动脉血流阻力,改善血管内皮功能,降低机体高凝状态,优化母婴结局。

Objective: To study the effect of compound Danshen injection combined with conventional western medicine treatment on disease condition,maternal and neonatal outcomes in early onset severe preeclampsia(EOSPE) patients. Methods: A total of 60 EOSPE patients in our hospital during December 2014 to February 2017 were selected,and randomly divided into a control group and an observation group,with 30 cases in each group.Patients in the control group were treated with routine western medicine,and those in the observation group were treated as the control group with addition of compound Danshen injection for 2 weeks.Ultrasound uterine artery blood flow parameters,peripheral blood vascular endothelial function and coagulation function indicators,and maternal and child outcomes were compared between two groups. Results: After two weeks of treatment,the artery pulsatility index (PI),resistance index (RI),umbilical artery blood flow S/D value,the content of serum endothelin-1 (ET-1) and the levels of (Fib),D-dimer (D-D) in peripheral blood were lower than those in the control group,while the content of nitric oxide (NO) in serum was higher,the prothrombin time (PT) and activated partial thromboplastin time (APTT) were shorter ( P <0.05).The incidence of adverse maternal and infant outcomes in the observation group was lower than that in the control group ( P <0.05). Conclusion: Compound Danshen injection combined with conventional western medicine could effectively decrease uterine artery resistance,improve endothelial function,and reduce the hypercoagulable state in EOSPE patients,thereby optimizing maternal and neonatal outcomes.