非瓣膜性心房颤动住院患者抗凝治疗的单中心调查分析

Single-center investigation and analysis of anticoagulation therapy in hospitalized patients with non-valvular atrial fibrillation

目的:调查分析非瓣膜性心房颤动(NVAF)住院患者抗凝治疗情况,为规范化抗凝治疗提供参考.方法:将NVAF患者按入院时间分为3组:2007~2010年(A组)、2011~2014年(B组)和2015~2017年(C组).调查3组患者抗凝及抗血小板药物使用情况,并进行栓塞及出血风险评估,对比分析不同栓塞风险、出血风险及不同组别间患者的抗凝治疗情况.结果:NVAF患者抗凝治疗率由4.15%(A组)上升至29.00%(C组),C组患者的抗凝治疗率较前显著增加(x^2=133.31,P<0.001).结论:NVAF患者的抗凝治疗较前有所改善,临床上应加强有效干预措施以提高抗凝治疗规范化程度.

Objective:To investigate and analyze the application situation of anticoagulant durgs in the hospitalized patients with non-valvular atrial fibrillation(NVAF),intending to provide reference to standardized anticoagulation therapy.Methods:The patients with NVAF in Department of Cardiology of our hospital was divided into 3 groups by date of hospitalization,from 2007 to 2010(group A),2011 to 2014(group B)and 2015 to 2017(group C).The application situation of anticoagulant and antiplatelet drugs in the patients was investigated.The risk of embolization and hemorrhage was assessed,and the risk of embolization and hemorrhage and the anticoagulation therapy among different groups was compared and analyzed.Results:The proportion of NVAF patients with anticoagulant treatment increased from 4.15%(group A)to 29.00%(group C).The proportion of patients with anticoagulant treatment in group C was higher than before(x^2=133.31,P<0.001).Conclusion:The anticoagulant treatment for NVAF patients has been improved,but more effective measures should be adopted to improve the standardization of anticoagulant therapy.