健脾生血颗粒治疗孕妇缺铁性贫血的临床效果以及对围产儿结局的影响

The clinical effect of Jianpi Shengxue Granule on iron deficiency anemia in pregnant women and its influence on perinatal outcome

目的为了提高孕妇缺铁性贫血的治疗效果并改善围产儿结局,分析采用健脾生血颗粒治疗的价值和意义。方法在本中心2017年8月~2018年8月治疗的缺铁性贫血孕妇中随机选78例作为研究对象,并通过抽签的方式平均将其分为对照组和观察组。其中对照组单纯予以多糖铁复合物胶囊治疗,观察组口服多糖铁复合物胶囊治疗的基础上辅以健脾生血颗粒治疗,比较不同用药方案在疗效、围产儿结局等方面的差异。结果治疗后观察组和对照组的总有效率分别为94.64%和66.07%,而围产儿不良结局发生率分别为2.56%和12.82%。和对照组相比,观察组治疗的总有效率更高(χ^2=6.30,P<0.05),而围产儿不良结局发生率更低(χ^2=7.34,P<0.05)。治疗后两组患者的各血液生化指标较治疗前均有所改善,观察组改善更占优势(P<0.05)。结论孕妇缺铁性贫血患者接受多糖铁复合物胶囊联合健脾生血颗粒治疗,既可以增强补血效果,改善血生化指标,还可以预防围生儿不良结局的发生,安全可靠。

Objective To improve the treatment effect of iron deficiency anemia in pregnant women and the perinatal outcome, and to analyze the value and significance of Jianpi Shengxue granule in the treatment of iron deficiency anemia. Methods A total of 78 pregnant women with iron deficiency anemia treated in the center from August 2017 to August 2018 were selected and randomly divided into control group and observation group on average by drawing lots. Patients in the control group were treated with polysaccharide-iron complex capsule alone. Patients in the observation group were treated with Jianpi Shengxue granule on the basis of oral polysaccharide-iron complex capsule. The difference of curative effect and perinatal outcome of the different medication regimens were compared. Results The data showed that the total effective rate of the observation group and the control group were 94.64% and 66.07%, respectively, while the incidence of adverse perinatal outcomes was 2.56% and 12.82%, respectively. Compared with the control group, the total effective rate of the observation group was highe(r χ^2=6.30, P <0.05), while the incidence of adverse perinatal outcomes was lower(χ^2=7.34, P <0.05). The blood biochemical indexes of the patients in both groups were improved compared with those before treatment, and the improvement of the observation group was more significant( P <0.05). Conclusion Polysaccharide- iron complex capsule combined with Jianpi Shengxue granule can not only enhance the effect of blood tonifying, improve blood biochemical indicators, but also prevent the occurrence of adverse perinatal outcomes, which is safe and reliable.