盐酸羟考酮注射液用于全麻患者术后镇痛的有效性和安全性研究

Efficacy and Safety of Oxycodone Hydrochloride Injection for Postoperative Analgesia in Patients with General Anesthesia

目的研究盐酸羟考酮注射液用于全麻患者术后镇痛的有效性和安全性。方法选取2017年1月~2018年1月在我院行全麻手术的82例患者作为研究对象,随机分为对照组和观察组,各41例。对照组术后采用硫酸吗啡注射液镇痛,观察组术后采用盐酸羟考酮注射液镇痛,对比两组患者术后不同时间疼痛度(VAS)评分、不良反应发生率以及满意度。结果观察组术后5、8、12、24h各时间点VAS评分低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为4.88%,低于对照组的17.07%,差异有统计学意义(P<0.05);观察组患者满意度为97.56%,高于对照组的87.80%,差异有统计学意义(P<0.05)。结论盐酸羟考酮注射液用于全麻患者术后镇痛效果良好,不良反应少,安全性高,具有较高的满意度。

Objective To study the efficacy and safety of oxycodone hydrochloride injection for postoperative analgesia in patients with general anesthesia. Methods 82 patients who underwent general anesthesia in our hospital from January 2017 to January 2018 were enrolled in the study. They were randomly divided into the control group and the observation group, with 41 cases in each group. The control group was treated with morphine sulfate injection for analgesia. The observation group was treated with oxycodone hydrochloride injection for analgesia. The pain score (VAS) score, adverse reaction rate and patient satisfaction were compared between the two groups. Results The VAS scores of the observation group at 5, 8,12 and 24 h after operation were lower than those of the control group,the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 4.88%, which was lower than 17.07% in the control group,the difference was statistically significant (P<0.05). The satisfaction of the observation group was 97.56%. In the control group, 87.80%, the difference was statistically significant (P<0.05). Conclusion Oxycodone hydrochloride injection is effective for postoperative analgesia in patients with general anesthesia, with less adverse reactions, high safety and high satisfaction.