氢氯吡格雷联合阿司匹林治疗急性脑梗死疗效分析

Efficacy analysis of hydroclopidogrel combined with aspirin on the treatment of acute cerebral infarction

目的探讨氢氯吡格雷联合阿司匹林治疗急性脑梗死患者的临床疗效。方法 86例急性脑梗死患者作为研究对象,按照随机数字表分为对照组和观察组,每组43例。两组患者均给予常规治疗,在此基础上,对照组患者采用阿司匹林治疗,观察组患者在对照组基础上联合氢氯吡格雷治疗。观察比较两组患者治疗前后的神经功能缺损、日常生活能力改善情况,并评估比较两组患者治疗效果及不良反应发生情况。结果观察组患者的治疗总有效率95.35%明显高于对照组的79.07%,差异有统计学意义(χ^2=5.11, P<0.05)。观察组患者的不良反应发生率6.98%(3/43)略低于对照组的9.30%(4/43),但差异无统计学意义(χ^2=0.16, P>0.05)。治疗后,观察组患者的美国国立卫生研究院卒中量表(NIHSS)评分(12.56±3.47)分明显低于对照组的(18.92±3.97)分,日常生活活动能力量表(ADL)评分(72.43±15.51)分明显高于对照组的(64.17±14.83)分,差异均有统计学意义(P<0.05)。结论针对急性脑梗死患者采用氢氯吡格雷联合阿司匹林治疗可有效改善神经功能缺损,增强其日常生活能力,且药物安全性较高,不良反应发生率较低,能够确保获得满意的治疗效果,治疗价值较高。

Objective To discuss the clinical efficacy of hydroclopidogrel combined with aspirin on the treatment of acute cerebral infarction. Methods A total of 86 patients with acute cerebral infarction as study subjects were divided by random number table method into control group and observation group, with43 cases in each group. Both groups received conventional therapy. On this basis, the control group was treated with aspirin, and the observation group was treated with hydroclopidogrel on the basis of the control group.Observation and comparison were made on neurological deficit and improvement of activity of daily living before and after treatment, treatment effect and occurrence of adverse reactions between the two groups. Results The observation group had obviously higher total treatment effective rate as 95.35% than 79.07% in the control group,and the difference was statistically significant(χ^2=5.11,P<0.05).The observation group had little lower incidence of adverse reactions as 6.98%(3/43) than 9.30%(4/43) in the control group,but the difference was not statistically significant(χ^2=0.16, P>0.05). After treatment, the observation group had obviously lower National Institutes of Health Stroke scale(NIHSS) score as(12.56±3.47) points than(18.92±3.97) points in the control group, and obviously higher activity of daily living(ADL) score as(72.43± 15.51) points than(64.17± 14.83) points in the control group, and the difference was statistically significant(P<0.05). Conclusion For patients with acute cerebral infarction, hydroclopidogrel combined,with aspirin therapy can effectively improve neurological deficits and enhance their activity of daily living with high drug safety and low incidence of adverse reactions. It can ensure satisfactory treatment effect and has high treatment value.