血脂康胶囊联合氨氯地平阿托伐他汀钙片治疗高血压并冠心病的临床疗效及炎性因子影响

Effect of Xuezhikang Ca psule Combined with Amlodipine Atorvastatin Calcium Tablets on Hypertension Complicated with Coronary Heart Disease and Inflammatory Factors

目的:探讨血脂康胶囊联合氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的临床效果及其对炎性因子的影响。方法:选取2017年1~12月在我院接受治疗的300例高血压合并冠心病患者作为研究对象,按照随机性原则随机分为对照组150例和观察组150例。对照组仅给予氨氯地平阿托伐他汀钙片治疗,观察组联合给予血脂康胶囊治疗。比较两组临床治疗效果及治疗前后血清炎性因子[C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)]水平变化。结果:对照组临床治疗总有效率(显效+有效)为68.00%,观察组为91.33%,两组比较差异具有统计学意义(P<0.05);治疗后两组舒张压和收缩压较治疗前均显著降低,心绞痛发作次数显著减少,且观察组治疗后血压水平和心绞痛发作次数均显著低于对照组(P<0.05);治疗后两组血清CRP、TNF-α及IL-6较治疗前也显著降低,且治疗后观察组上述血清炎性因子水平均显著低于对照组(P<0.05)。结论:对高血压合并冠心病在常规氨氯地平阿托伐他汀钙片治疗的基础上联合给予血脂康胶囊治疗能显著提高疗效,促进血压降低和心绞痛发作次数的减少,还能有效促进炎症因子水平的降低,有利于改善机体的状态,且不会增加不良反应的发生率,值得临床推广。

Objective:To investigate the clinical effect of Xuezhikang capsule combined with amlodipine atorvastatin calcium tablets on hypertension complicated with coronary heart disease and its influence on inflammatory factors. Methods:300 patients with hypertension and coronary heart disease were randomly divided into control group (150 cases)and observation group (150 cases). Patients in the control group were given amlodipine atorvastatin calcium tablets,while patients in the observation group were added Xuezhikang capsules treatment. The clinical efficacy and serum levels of inflammatory factors (CRP,TNF-a and IL-6)were compared between the two groups before and after treatment. Results:The total effective rate (marked effect + effective)was 68.00% in the control group and 91.33% in the observation group. The difference between the two groups was statistically significant(P<0.05). The serum levels of CRP, TNF-a and IL-6 in the two groups were significantly lower than those in the control group (P<0.05),and the levels of inflammatory factors in the two groups were significantly lower than those in the control group (P<0.05). Conclusion:Xuezhikang capsule combined with amlodipine and atorvastatin calcium tablets can significantly improve the curative effect,promote the decrease of blood pressure and angina pectoris attack frequency in patients with hypertension complicated with coronary heart disease,and it can also effectively promote the reduction of related inflammatory factors,which is beneficial to improvement. The state of the patient's body does not increase the incidence of adverse reactions,and is worthy of clinical application.