阿仑膦酸钠联合NSAIDs通过调节炎症水平和骨代谢改善AS患者幸福指数

Effects of alendronate combined therapy on quality of life and bone metabolism in AS patients

目的:探讨阿仑膦酸钠(AL)联合疗法通过调节炎症水平和骨代谢改善AS患者幸福指数的临床可行性。方法:选取2015年4月~2016年4月AS患者72例,随机分为常规组36例和联合组36例,两组均进行非甾体类抗炎药物(NSAIDs)治疗,并配合锻炼治疗,观察组加用AL进行治疗,对比两组VAS疼痛评分、骨代谢指标以及幸福指数。结果:治疗后VAS疼痛评分平均值随着时间延长而降低,AL联合NSAIDs组治疗后VAS评分降低更为显著,优于对照组(P<0.01)。两组BGP、OPG血清检测结果表明联合组血清骨代谢指标提高更为显著(P<0.05或0.01)。从机体方面、生活方面、心理方面三个方面评估生活幸福质量,联合组幸福感更高(P<0.01)。结论:阿仑膦酸钠联合非甾体类抗炎药降低AS患者疼痛,改善骨代谢,提高生活幸福感。

Objective:To analyze the feasibility of alendronate sodium(AL)combined therapy in the treatment of ankylosing spondylitis(AS). Methods:Seventy-two patients with AS from April 2015 to April 2016 were randomly divided into routine group(36 cases)and combined group(36 cases). Both groups were treated with non-steroidal anti-inflammatory drugs,combined with exercise therapy. The observation group was treated with AL,and the clinical effects of the two groups were compared. Result:The VAS pain score of the two groups decreased with the course of treatment,and still decreased after withdrawal. Compared with the routine group,the VAS score of the combined group decreased more significantly(P<0.01). Compared with before treatment,the serum levels of BGP and OPG in the two groups were significantly improved after treatment,and the serum bone metabolism index in the combined group was significantly increased(P<0.05 or 0.01). The quality of life well-being was assessed from three aspects of patients’ body,life and psychology. The total score of life well-being in the combined group was significantly higher than that in the conventional group(P<0.01). Conclusion:Alendronate sodium combined with NSAIDs can reduce pain,improve bone metabolism and improve the well-being of patients with AS.