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肝动脉化疗栓塞术(TACE)联合二甲双胍对原发性肝癌的临床应用疗效研究 被引量:2

Clinical application of transcatheter arterial chemoembolization(TACE) combined with metformin in patients with primary liver cancer
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摘要 目的:探讨原发性肝癌采用肝动脉化疗栓塞术(TACE)联合二甲双胍治疗的临床疗效。方法:选取我院(2015年1月~2017年1月)收治的84例原发性肝癌患者为研究对象,根据不同治疗方法分为两组,观察组42例给予TACE联合二甲双胍治疗,对照组42例给予TACE治疗,1年后对比两组疾病控制率和生存质量以及TBIL、ALT、AFP改善情况。结果:观察组疾病控制率和生存质量提高稳定率以及TBIL、ALT、AFP改善率均明显高于对照组,差异具有统计学意义(P<0.05)。结论:TACE联合二甲双胍治疗原发性肝癌效果显著,可有效控制疾病进展,改善生活质量,保护肝功能,值得临床推广。 Objective:To investigate the clinical efficacy of transcatheter arterial chemoembolization(TACE)combined with metformin in patients with primary liver cancer. Methods:Eighty-four patients with primary liver cancer admitted to our hospital (January 2015 to January 2017)were enrolled in the study. They were divided into two groups according to different treatment methods. 42 patients in the observation group were treated with TACE combined with metformin. Forty-two patients were treated with TACE. After 1 year,the disease control rate and quality of life and the improvement of TBIL,ALT and AFP were compared between the two groups. RESULTS: The improvement rate of disease control rate and quality of life and the improvement rate of TBIL,ALT and AFP in the observation group were significantly higher than those in the control group(P<0.05). Conclusion:TACE combined with metformin is effective in the treatment of primary liver cancer,which can effectively control the disease progression,improve the quality of life and protect liver function. It is worthy of clinical promotion.
作者 马志勇 李雪平 李昌安 汪明强 Ma Zhiyong;Li Xueping;Li Changan;Wang Mingqiang(General Surgery,The 153th Central Hospital of PLA,Zhengzhou 450000,China)
机构地区 解放军第
出处 《北方药学》 2019年第7期80-81,共2页 Journal of North Pharmacy
关键词 原发性肝癌 肝动脉化疗栓塞术 二甲双胍 临床疗效 Primary liver cancer Transcatheter arterial chemoembolization Metformin Clinical efficacy
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