心脏瓣膜术后氧化应激水平变化与新发心房颤动的关系

Relationship between postoperative oxidative stress level changes and newly onset atrial fibrillation in valvular patients

目的探讨心脏瓣膜术后氧化应激水平变化与新发心房颤动的关系。方法连续入选2015年4月至2016年8月于阜外医院拟行心脏瓣膜手术且无心房颤动的患者122例。收集患者术前基线资料,测量术前、术后血浆中氧化应激指标丙二醛加成产物水平,分析其变化与新发心房颤动的关系。结果与术前比较,所有患者术后丙二醛加成产物显著升高[(89.97±3.17)ng/ml比(75.30±2.86)ng/ml,P<0.01]。术后新发心房颤动的患者丙二醛加成产物较无新发心房颤动的患者上升更高[分别上升(24.29±3.66)ng/ml和(9.24±1.80)ng/ml,P<0.01]。回归分析证实,循环丙二醛加成产物上升与术后新发心房颤动显著相关(OR:1.04,95%CI:1.02~1.07,P<0.01)。结论心脏瓣膜术后氧化应激水平上升与新发心房颤动显著相关。

Objective This study reports the relationship between the postoperative oxidative stress level changes and newly onset atrial fibrillation in valvular patients. Methods The preoperative baseline data were continuously collected from 122 patients without atrial fibrillation between April 2015 to August 2016, and the preoperative and postoperative plasma stress levels (malondialdehyde adducts) were measured. The relationship between the changes of the stress index and the newly onset atrial fibrillation was analyzed. Results Postoperative stress levels were significantly higher than that before operation [(89.97±3.17)ng/ml vs.(75.30±2.86)ng/ml, P <0.01]. Patients got newly onset atrial fibrillation had higher stress level increase than patients got normal heart rhythm [(24.29±3.66) ng/ml vs.(9.24±1.80) ng/ml, P < 0.01]. Conclusions The newly onset atrial fibrillation after cardiac surgery is significantly associated with the increase of stress level.