对比分析α-硫辛酸和甲钻胺在糖尿病周围神经病变治疗中的疗效

Comparative analysis of the efficacy of α-lipoic acid and methotrexate in the treatment of diabetic peripheral neuropathy

目的研究探讨α-硫辛酸、甲钻胺在糖尿病周围神经病变治疗中的疗效。方法选取2017年1月至2018年6月本院收治的80例糖尿病周围神经病变患者为研究对象,随机均分两组,各40例,以甲钻胺治疗为对照组,以α-硫辛酸、甲钻胺联合治疗为观察组。分析α-硫辛酸、甲钻胺联合治疗的价值所在,并对比两组的疗效、周围神经传导,VAS评分。结果观察组总有效率为92.5%,对照组总有效率为80.0%,观察组疗效高于对照组,周围神经传导速度优于对照组,VAS评分低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为5.0%,对照组为12.5%,两组差异有统计学意义(P<0.05)。结论对于糖尿病周围神经病变患者,采取α-硫辛酸、甲钻胺联合治疗,效果显著,可以增强疗效,改善周围神经病变症状,减轻患者的疼痛,值得在今后的治疗中应用。

Objective To investigate the efficacy of α-lipoic acid and methotrexate in the treatment of diabetic peripheral neuropathy. Methods 80 patients with diabetic peripheral neuropathy admitted to our hospital from January 2017 to June 2018 were enrolled in the study. They were randomly divided into two groups, 40 cases each. The treatment with methotrexate was used as the control group, with α-lipoic acid, Combination therapy with methotrexate was observed. To analyze the value of combined treatment with α-lipoic acid and methotrexate, and compare the efficacy of the two groups, peripheral nerve conduction, VAS score. Results The effective rate of the observation group was 92.5%, and the effective rate of the control group was 80.0%. The effect of the observation group was higher than that of the control group. The peripheral nerve conduction velocity was better than that of the control group, and the VAS score was lower than that of the control group. The difference was statistically significant (P<0.05);the incidence of adverse reactions in the observation group was 5.0%, and that in the control group was 12.5%. The difference between the two groups was statistically significant (P<0.05). Conclusion For patients with diabetic peripheral neuropathy, the combination of α-lipoic acid and methotrexate has significant effect, which can enhance the curative effect, improve the symptoms of peripheral neuropathy, and alleviate the pain of patients. It is worthy of application in future treatment.