蓝光照射联合双歧杆菌治疗新生儿ABO溶血性黄疸临床观察

Clinical observation on treatment of Neonatal ABO hemolytic jaundice with Nlue light combined with Bifidobacterium

目的观察间歇蓝光照射联合双歧杆菌三联活菌制剂治疗新生儿ABO溶血性黄疸的临床疗效。方法选取入住本院新生儿科ABO溶血性黄疸新生儿60例,随机分为两组,对照组采用输液、清蛋白静滴、口服苯巴比妥钠等常规治疗的同时给予间歇性蓝光治疗;治疗组在常规治疗方法及间歇蓝光照射基础上口服双歧杆菌活菌制剂。观察两组患儿黄疸消失时间、住院治疗后血清胆红素水平的变化、治疗过程中经皮黄疸指数的变化、不良反应的情况。结果对照组和治疗组黄疸消失时间分别为(6.0±2.0)d、(4.0±2.5)d,治疗组黄疸消失时间较对照组明显缩短,差异有统计学意义(P<0.01);治疗后,两组血清总胆红素值分别为(84.0±34.8)、(40.4±16.5)μmol/L,两组比较差异具有统计学意义(P<0.01)。两组患儿治疗第1天、第2天、第4天、第5天、第6天经皮测胆红素数值变化的比较,差异均有统计学意义(P<0.05);治疗组经皮黄疸指数水平较对照组明显降低;治疗组的不良反应发生率为6.67%,低于对照组的20.00%,差异有统计学意义(P<0.01)。结论间歇蓝光照射联合双歧杆菌治疗新生儿ABO黄疸有效果显著,不良反应少,安全性高,值得临床推广及应用。

Objective To observe the clinical effect of intermittent blue light irradiation combined with bifid Lriple viable in treatment of neonatal ABO hemolytic jaundice. Methods In our hospital 60 cases of neonatal ABO hemolytic jaundice, were randomly divided into two groups, the control group using albumin infusion, intravenous, oral phenobarbital were treated with intermittent blue light treatment;treatment group in conventional treatment method and intermittent blue light irradiation on the basis of live Bifidobacterium oral preparation and observation of two groups of children with jaundice disappeared time, hospitalization serum bilirubin levels after treatment, the treatment process changes of transcutaneous jaundice index, adverse reaction. Results The disappearance time of jaundice in the control group and the treatment group was (6.0±2.0) days and (4.0± 2.5) days, respectively. The disappearance time of jaundice in the treatment group was significantly shorter than that in the control group, the difference was statistically significant (P<0.01), the serum total bilirubin level of the two groups was (84.0±34.8)μmol/L and (40.4±16.5)μmol/L, respectively, and there was significant difference between the two groups (P<0.01). The changes of bilirubin were measured on the 1st, 2nd, 4th, 5th and 6th day after treatment. The difference was statistically significant (P<0.05). The level of percutaneous jaundice index in the treatment group was significantly lower than that in the control group. The incidence of adverse reactions in the treatment group was lower than that in the control group (6.67% vs 20.00%, P<0.01). Conclusion Intermittent blue light irradiation combined with Bifidobacterium in the treatment of neonatal ABO jaundice has significant effects, fewer adverse reactions and higher safety. It is worth popularizing and applying in clinic.