前向运动精子总数对促排卵周期宫腔内人工授精妊娠结局的影响

The effect of the total progressively motile sperm count on the outcome of intrauterine insemination

目的探究宫腔内人工授精(intrauterine insemination,IUI)中精液洗涤后前向运动精子总数(total progressively motile sperm count,TPMSC)对临床妊娠结局的影响。方法回顾性分析于滨州医学院附属医院生殖医学中心(2006年7月—2017年7月)进行宫腔内人工授精的1 147个促排卵方案周期,观察TPMSC对临床妊娠率的影响。将所有周期按照TPMSC分为四个组,分别为<5×10^6组、(5~10)×10^6组、(10~20)×10^6组以及>20×10^6组,观察各组之间的临床妊娠率有无差异。结果所有周期中总的临床妊娠率为25.7%,四组临床妊娠率分别为25.3%(25/99)、26.7%(51/191)、27.0%(90/333)和24.7%(129/523),差异无明显统计学意义(P>0.05)。结论本次研究发现,促排卵方案的IUI周期中,处理后前向运动精子总数(TPMSC)<10×10^6仍能得到较满意的临床结局。

Objective To investigate the effect of total progressively motile sperm count(TPMSC)on clinical pregnancy outcome in intrauterine insemination(IUI).Methods A retrospective analysis was made on 1 147 Ovarian stimulation cycles of intrauterine insemination at the Reproductive Center of the Affiliated Hospital of Binzhou Medical university.The effect of TPMSC on clinical pregnancy rate was observed.According to the value of TPMSC,all cycles were divided into<5 × 10^6 group,(5 ~10)×10^6 group,(10~20)×10^6 group and>20×10^6 group.The clinical pregnancy rate among the groups was observed.Results The total clinical pregnancy rate in all cycles was 20.7%.The clinical pregnancy rates in four groups were 25.3%(25/99),26.7%(51/191),27.0%(90/333),24.7%(129/523),respectively,with no significant difference(P>0.05).Conclusion This study found that the total progressively motile sperm count(TPMSC)<5 × 10^6 could still achieve good clinical outcomes in IUI cycles of Ovarian stimulation.